Results 291 to 300 of about 1,170,924 (343)

Molecular dynamics of the host response to Streptococcus pneumoniae pneumonia in baboons

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Using an established, clinically relevant nonhuman primate model of S. pneumoniae pneumonia, this study aims to identify novel potential molecular diagnostic and therapeutic targets using peripheral blood bulk transcriptomic, unbiased proteomic, and cytokine measurements. The constructed models were highly accurate in classifying bacterial pneumonia in
Bryan D. Kraft   +18 more
wiley   +1 more source

Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Tirzepatide: A peptide‐based GLP‐1/GIP receptor agonist, tested on L‐Arginine‐induced pancreatitis. Lipase/Amylase Levels: Initially elevated due to inflammation but normalized with Tirzepatide. Inflammatory Response: Reduction in pro‐inflammatory cytokines (IL‐6) and enhancement of anti‐inflammatory cytokines (IL‐4, IL‐10).
Razan Alawaji   +9 more
wiley   +1 more source

Pimobendan alleviates myocyte apoptosis and fibrosis associated with mitral regurgitation by targeting endoplasmic reticulum stress

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Mitral regurgitation (MR) causes volume overload and disrupts Ca2+ homeostasis. The volume overload leads to cardiac hypertrophy and fibrosis inferred from histopathological studies. Cardiac hypertrophy was identified by increased myocyte cross‐sectional area, left atrial‐to‐aortic root ratio, and left ventricular internal diameter at end‐diastole ...
Pakit Boonpala   +10 more
wiley   +1 more source

Antiviral and immunomodulatory effects of Chaihu Guizhi decoction in an acute depression‐like mouse model infected with influenza A virus

open access: yesAnimal Models and Experimental Medicine, EarlyView.
CGD alleviates depression‐like symptoms by increasing the levels of DA and NE. Furthermore, CGD downregulates the relative expression of M gene, calms the cytokine storm, and maintains the balance of Th17/Treg cells in virus infected mice. CGD exhibits a protective effect in mice with depression‐like symptoms infected with IAV, providing preclinical ...
Ran Shi   +7 more
wiley   +1 more source

Correlation of sonographic and radiographic scores of lung edema and metrics of shunt, dead space, and respiratory mechanics in invasively ventilated patients. [PDF]

open access: yesCrit Care Sci
Filippini D   +11 more
europepmc   +1 more source

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