Results 61 to 70 of about 978,459 (257)
Structural and biochemical analysis of a B12 superbinder
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Animation Visualization for Vertex Coloring of Polyhedral Graphs [PDF]
Vertex coloring of a graph is the assignment of labels to the vertices of the graph so that adjacent vertices have different labels. In the case of polyhedral graphs, the chromatic number is 2, 3, or 4. Edge coloring problem and face coloring problem can
Hidetoshi Nonaka
doaj
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Fuzzy Edge Chromatic Number of the Join of Fuzzy Graphs and Its Applications
Fuzzy edge coloring has proven to be a powerful tool for modeling and optimizing complex network systems, owing to its ability to effectively represent and manage the uncertainty in relational strengths and conflicts.
Jing Qu, Qian Wang, Angmo Deji
doaj +1 more source
Antipodal Edge-Colorings of Hypercubes
Two vertices of the k-dimensional hypercube Qkare antipodal if they differ in every coordinate. Edges uv and xy are antipodal if u is antipodal to x and v is antipodal to y.
West Douglas B., Wise Jennifer I.
doaj +1 more source
On the classification of motions of paradoxically movable graphs
Edge lengths of a graph are called flexible if there exist infinitely many non-congruent realizations of the graph in the plane satisfying these edge lengths. It has been shown recently that a graph has flexible edge lengths if and only if the graph has
Georg Grasegger +2 more
doaj +1 more source
Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise +5 more
wiley +1 more source
Smaller is better: nanobodies meet NMR
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source

