Results 91 to 100 of about 1,240,803 (294)

Determining the Parameters of Leveler-Ripper Shanks

open access: yesСельскохозяйственные машины и технологии, 2019
In order to ensure high-quality sowing and smooth seed germination, the main task in pre-sowing soil preparation is fi eld surface leveling, soil compaction to the required degree and the formation of a mildly mulching layer on the soil surface.
Kh. G. Abdulkhaev, M. M. Khalilov
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

open access: yesMolecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié   +16 more
wiley   +1 more source

The Effect Edge Preparation Onto the Damageability of Protective Covering Under Arc Brazing of Galvanized Steel [PDF]

open access: yes, 2010
THE EFFECT EDGE PREPARATION ONTO THE DAMAGEABILITY OF PROTECTIVE COVERING UNDER ARC BRAZING OF GALVANIZED STEEL / канд. техн. наук, доц. Ю.А. ЦУМАРЕВ (Белорусско-Российский университет, Могилев); д-р техн. наук, проф. В.К.
Цумарев, Ю. А.   +1 more
core  

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

open access: yesMolecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker   +16 more
wiley   +1 more source

Simulation and Experimental Study on the Effect of Edge Radius on the Cutting Condition of Carbide Inserts

open access: yesMachines
Carbide tools are extensively used in the automotive, aerospace, and marine industries. However, an unsuitable tool-edge treatment can affect the cutting performance of carbide tools.
Shitao Chen   +9 more
doaj   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Interference measurements of non-Abelian e/4 & Abelian e/2 quasiparticle braiding

open access: yes, 2021
The quantum Hall states at filling factors $\nu=5/2$ and $7/2$ are expected to have Abelian charge $e/2$ quasiparticles and non-Abelian charge $e/4$ quasiparticles.
.   +8 more
core  

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