Results 61 to 70 of about 1,240,803 (294)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
Artifacts from manganese reduction in rock samples prepared by focused ion beam (FIB) slicing for X-ray microspectroscopic analysis [PDF]
, 2018 . Manganese (Mn)-rich natural rock coatings, so-called rock varnishes, are discussed controversially regarding their genesis. Biogenic and abiogenic mechanisms, as well as a combination of both, have been proposed to be responsible for the Mn oxidation ...
Andreae, Meinrat O +9 more
core
Discrete curvature approximations and segmentation of polyhedral surfaces [PDF]
, 2005 The segmentation of digitized data to divide a free form surface into patches is one of the key steps required to perform a reverse engineering process of an object.
LEON, Jean-Claude +2 more
core +6 more sources
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Porcelain veneers - preparation design: A retrospective review [PDF]
, 2014 This paper discusses the preparation of tooth design for porcelain veneers. It follows the literature more than three decades back in the past. From the very beginning, porcelain veneers were placed to no/minimally prepared tooth substance ...
Dodić Slobodan M. +5 more
core +1 more source
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
Reducing the Aspect Ratio of Contact Holes by In-Situ Low-Angle Cross Sectioning
, 2015 Auger analysis of high-aspect ratio contact holes of integrated microelectronic devices is a challenging analytical task. Due to geometrical shadowing the primary electron beam and the energy analyser have not the required direct line of sight to the ...
Scheithauer, Uwe
core +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Influence of the preparation processes on the residual stresses in PCD and PcBN tools
European Journal of MaterialsUltra-hard cutting materials such as polycrystalline diamond (PCD) and cubic boron nitride (PcBN) are increasingly being used as cutting tools in machining.
Bernd Breidenstein +2 more
doaj +1 more source
Influence of the Butt Joint Design of TIG Welding on the Thermal Stresses [PDF]
Engineering and Technology Journal, 2011 The aim of this paper is to demonstrate the influence of the single butt joint design of TIG welding on the thermal stresses for carbon steel type St-37.
Hani Aziz Ameen +2 more
doaj +1 more source