Results 71 to 80 of about 1,240,803 (294)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Theoretical Estimate of the Effect of the Parameters of the Circulating Movement of the Workpiece on the Intensity of Its Cutting. [PDF]

, 2014
Рассматривается проблема повышения интенсивности распиливания при сообщении эллиптического движения распиливаемой заготовке. В ходе проведения исследования получены зависимости величины импульса ударной силы, действующего в процессе ударно-фрикционного ...
Габец, В. Л., Дроздов, А. В., Киселев, М. Г., Ямная, Д. А.   +3 more
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Bright gap solitons of atoms with repulsive interaction

, 2004
We report on the first experimental observation of bright matter-wave solitons for 87Rb atoms with repulsive atom-atom interaction. This counter intuitive situation arises inside a weak periodic potential, where anomalous dispersion can be realized at ...
B. Eiermann, C. M. de Sterke, G. P. Agrawal, G. P. Agrawal, K.-P. Marzlin, L. Khaykovich, M. Albiez, M. K. Oberthaler, M. Taglieber, N. Ashcroft, P. Meystre, P. Treutlein, Th. Anker   +12 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Effects of Tool Edge Geometry on Chip Segmentation and Exit Burr: A Finite Element Approach

Metals, 2019
The effects of different tool edge geometries (hone and chamfer (T-land)) on quantitative measurement of end (exit) burr and chip segmentation (frequency and degree) in machining of AA2024-T351 are presented in this work. The finite element (FE) approach
Muhammad Asad
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

"So many people going the other way" : an examination of the moral strategy of language usage in five novels by Janet Frame : a thesis presented in partial fulfilment of the requirements for the degree of Master of Arts in English at Massey University [PDF]

, 1991
The title quotation is from Janet Frame's novel, Living in the Maniototo (72). Abbreviations and editions of the five primary sources referred to in the text are as follows: EA The Edge of the Alphabets London: W.H. Allen & Co., 1962.
Pound, Lynette Ruth
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