Results 111 to 120 of about 4,529,106 (309)
Postsynaptic Complexin Mediates Constitutive Exocytosis of Nicotinic Acetylcholine Receptor
Advanced Science, EarlyView.Beyond its established presynaptic role, complexin is identified as a postsynaptic regulator of neurotransmitter receptor trafficking. By promoting constitutive and activity‐dependent exocytosis of nicotinic acetylcholine receptors, complexin controls spontaneous synaptic signaling at the C.
Ya Wang +4 more
wiley +1 more source
A Numerical Guide to Volume 2 of the Guidelines and Practical Advice on how to Transpose them into National Standards [PDF]
, 2008 [INTRODUCTION] In 2006, the World Health Organization published the third edition of the Guidelines, in collaboration with FAO and UNEP. The third edition consist of four volumes; volume 2, explained in this guidance note, addresses methods, procedures ...
Mara, D.D.
core
Genome editing of human embryos: to edit or not to edit, that is the question [PDF]
Journal of Clinical Investigation, 2017 Srinivasan Chandrasegaran +2 more
openaire +2 more sources
Advanced Science, EarlyView.HNRNPD promotes radioresistance in nasopharyngeal carcinoma by enhancing stress granule assembly and sequestering GRAMD4 mRNA. This suppresses GRAMD4 translation and inhibits mitochondrial apoptosis. Targeting the integrated stress response with ISRIB restores GRAMD4 expression and sensitizes tumors to radiotherapy, revealing a translational control ...
Yingzi Li +13 more
wiley +1 more source
Giving in Minnesota, 2008 Edition [PDF]
, 2008 The Minnesota Council on Foundations has produced Giving in Minnesota, 2008 Edition to provide a comprehensive analysis of philanthropy in the state. The 2008 edition features overall giving in 2006, the most recent year for which comprehensive data are ...
Anne Graham, Wendy Wehr
core
Advanced Science, EarlyView.The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi +13 more
wiley +1 more source
The Cowl - v.31 - Special Edition - May 01, 1969 [PDF]
, 1969 The Cowl - student newspaper of Providence College. Volume 31, Special Edition - May 1, 1969.
core +1 more source
Mapping the “Supply–Demand–Flow” of Ecosystem Services for Ecosystem Management in China
Advanced Science, EarlyView.This study develops a “supply–demand–flow” framework clarifies how ecosystem services move between regions by distinguishing potential and actual supply and demand. Using integrated biophysical–socioeconomic modeling, nine services in China were mapped.
Yikun Zhang +3 more
wiley +1 more source
The Cowl - Special Edition - Apr. 26, 1993 [PDF]
, 1993 The Cowl - student newspaper of Providence College. Special Edition - April 26, 1993.
core +1 more source
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
Advanced Science, EarlyView.This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source