Results 31 to 40 of about 794,025 (286)

La investigación formativa como una necesidad en el pregrado

open access: yesRevista Colombiana de Ciencia Animal Recia, 2012
Según La Real Academia de la Lengua Española (http://www.rae.es/) se define investigar como la realización de actividades intelectuales y experimentales de modo sistemático con el propósito de aumentar los conocimientos sobre una determinada materia.
V. JAIME DE LA OSSA   +3 more
doaj   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu   +8 more
wiley   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns   +10 more
wiley   +1 more source

REVISÃO SISTEMÁTICA DA LITERATURA: CONCEITUAÇÃO, PRODUÇÃO E PUBLICAÇÃO

open access: yesLogeion Filosofia da Informação, 2019
Realizar uma revisão sistemática de literatura vai além da atividade usual de fazer uma revisão de literatura como parte de um trabalho de pesquisa acadêmica.
M. C. B. Galvão, I. Ricarte
semanticscholar   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Autores e editores de compêndios e livros de leitura (1810-1910)

open access: yes, 2004
This article presents considerations about the issue of the authorship of schoolbooks. The role of the authors of a schoolbook has been a controversial topic due to its ambiguity with respect to their rights and legal accountability.
Circe Bittencourt
semanticscholar   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

Fórum de Editores Científicos em Saúde Pública

open access: yes, 2007
Em agosto de 2006, durante a realização do 8o Congresso Brasileiro de Saúde Coletiva e 11o Congresso Mundial de Saúde Pública, a Revista de Saúde Pública organizou, como parte das atividades de comemoração dos seus 40 anos de existência, o Fórum de ...
C. A. Monteiro, R. Barata
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Cenário das revistas geridas pelos participantes do curso de editoração científica da ABEC

open access: yesCiência da Informação em Revista, 2018
O Curso de Editoração Científica (CEC), promovido pela Associação Brasileira de Editores Científicos (ABEC Brasil), procura discutir os principais temas de interesse dos editores brasileiros.
Milton Shintaku   +5 more
doaj   +1 more source

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