Results 71 to 80 of about 1,249,346 (252)
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Advanced Science, EarlyView.In an invasive beetle–fungus complex, the mutualist Leptographium procerum induces host HSP83 and modulates Toll‐dependent antifungal immunity. HSP83 mediates two‐tiered control by associating with selected fungal recognition receptors and restraining Dorsal‐driven antimicrobial peptide transcription.
Qingtai Yang +8 more
wiley +1 more source
Editorial: Neuroanaesthesiology editorial [PDF]
Current Opinion in Anaesthesiology, 2021 Nadia, Stellema, Anthony R, Absalom
openaire +2 more sources
Advanced Science, EarlyView.TUBA1B is consistently upregulated in hepatocellular carcinoma and sustains malignant progression by stabilizing G3BP2. By restraining TRIM25‐associated K48‐linked ubiquitination, TUBA1B preserves the G3BP2–IκBα complex and basal NF‐κB/p65 activity. Concurrent TUBA1B/G3BP2 upregulation identifies an aggressive HCC subgroup with enhanced p65 activation ...
Fen Lin +10 more
wiley +1 more source
Gaceta Sanitaria en 2017. Mejorando la calidad de nuestra revista
Gaceta Sanitaria, 2018 Clara Bermúdez-Tamayo +19 more
doaj +1 more source
Fin de ciclo editorial: ¡gracias totales!
Nuestras AvesEste trabajo no cuenta con un ...
Lucía Mentesana, Nicolás Adreani
doaj +1 more source
Advanced Science, EarlyView.Organic electrochemical transistors bridge biological ionic signaling and neuromorphic computation through volumetric electrochemical gating. This review connects Organic mixed ionic–electronic conductor materials, device architectures, and manufacturing technologies to show how geometry, ion transport, and fabrication strategies program plasticity ...
Hyunjin Lee +5 more
wiley +1 more source
Gaceta Sanitaria en 2016. Una nueva etapa, fortalecimiento de eGaceta e internacionalización
Gaceta Sanitaria, 2017 Clara Bermúdez-Tamayo +20 more
doaj +1 more source
Engineered Transformer Base Editor with Enhanced Editing Efficiency
Advanced Science, EarlyView.A highly efficient transformer base editor system achieves robust genomic editing in a humanized mouse model. This work establishes a versatile and translatable platform, opening new avenues for precision gene therapy. ABSTRACT Canonical cytosine base editors (CBEs) achieve precise C‐to‐T conversions without inducing DNA double‐strand breaks (DSBs ...
Bowen Chen +5 more
wiley +1 more source