Results 191 to 200 of about 3,176,468 (279)

Comparative analysis of short‐term and long‐term LL‐37‐induced rosacea‐like mouse models: Histopathological features and inflammatory immune responses

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu   +10 more
wiley   +1 more source

Comparison of the pathogenicity of multiple SARS‐CoV‐2 variants in mouse models

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We assessed the pathogenicity of various SARS‐CoV‐2 variants using two distinct mouse models. Our findings indicated that earlier variants, including WH‐09, Beta, and Delta, exhibited greater pathogenicity than later variants. Specifically, the Omicron variant demonstrated reduced pathogenicity, characterized by a shorter disease course and diminished ...
Qi Lv   +12 more
wiley   +1 more source

Pbs2 regulates late‐stage macroautophagy in Saccharomyces cerevisiae

open access: yesAnimal Models and Experimental Medicine, EarlyView.
The MAPK family member Pbs2 and its role in autophagy. Macroautophagy consists of five key steps: the initiation at the pre‐autophagosomal structure (PAS), elongation of the isolation membrane (IM), maturation of the autophagosome, fusion of autophagosomes with vacuoles, and degradation of autophagic bodies.
Jianing Song   +8 more
wiley   +1 more source

Comparative analysis of two newly established Cre rat lines, NeuN‐Cre and Thy1‐Cre, for neurological research

open access: yesAnimal Models and Experimental Medicine, EarlyView.
We generated two neuron‐specific Cre rat lines, Thy1‐Cre and NeuN‐Cre, using CRISPR/Cas9‐mediated targeted insertion. Both lines were validated for high neural specificity by crossing them with a Cre reporter rat. When bred with an ND1 conditional knockout rat, the two Cre lines produced distinct phenotypic outcomes. These rat lines have been deposited
Keru Li   +15 more
wiley   +1 more source

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