Results 31 to 40 of about 2,868,920 (272)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Editorial note to: Brandon Carter, Large number coincidences and the anthropic principle in cosmology [PDF]

, 2011
This is an editorial note to accompany reprinting as a Golden Oldie in the Journal of General Relativity and Gravitation of the famous paper by Brandon Carter on the anthropic principle in cosmology \cite{Car74}. This paper was presented at IAU Symposium
G. Ellis
semanticscholar   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

EDITORIAL NOTE ON REPRODUCTIVE BIOLOGY OF FISHES

, 2013
Fish reproductive biology (onset and duration of spawning, sex ratio, maturity stages, length and age at maturity, and fecundity) is important in fisheries research, stock assessment, and management.
Athanassios C. Tsikliras, K. Stergiou, R. Froese   +2 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Editorial note to: J. Ehlers, F. A. E. Pirani and A. Schild, The geometry of free fall and light propagation

General Relativity and Gravitation, 2012
The article by Jürgen Ehlers, Felix Pirani, and Alfred Schild (EPS), reprinted here as a Golden Oldie, is devoted to the problem of deriving the Lorentzian geometry that underlies the space-time of general relativity from compatible conformal and ...
A. Trautman
semanticscholar   +1 more source

Editorial [PDF]

, 2017
Editorial de Manuscrits 35: Autocensura i historiografia en temps dels Àustries.Editorial de Manuscrits 35: Autocensura e historiografía en tiempos de los ÀustriasEditorial note of Manuscrits 35: Self-censorship and historiography in Habsburg ...
Ignasi Fernández Terricabras, Fernández Terricabras, Ignasi   +1 more
core   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Editorial note to: Matvei P. Bronstein, Quantum theory of weak gravitational fields [PDF]

, 2011
Quantization of gravity · Bronstein · Golden OldieBronstein’s is only the second work, after L. Rosenfeld’s 1930 papers [1,2], on thequantizationof(linearized)gravity.Itwascarriedoutin1935,atatimewhenmodernquantum field theory was in its infancy—well ...
S. Deser, A. Starobinsky
semanticscholar   +1 more source