Results 121 to 130 of about 46,919 (228)

The Mycobacterium tuberculosis Rv0132c Gene Product Mtb‐FGD2 Can Act as an F420‐Dependent Glucose Dehydrogenase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT The role of the cell envelope‐associated Rv0132c/FGD2 from Mycobacterium tuberculosis has long been a subject of debate. Importantly, FGD2 is found only in pathogenic mycobacteria, making it a potential drug target. While some suggest it functions as a glucose‐6‐phosphate dehydrogenase, others propose it acts instead as an F420‐dependent ...
Adewale V. Aderemi, Matthew Snee, Richard B. Tunnicliffe, Linus O. Johanissen, Matthew J. Cliff, Colin W. Levy, Derren J. Heyes, Marina Golovanova, Thomas A. Jowitt, Sam Hay, Andrew W. Munro, Jonathan P. Waltho, David Leys   +12 more
wiley   +1 more source

Message by the Editor-in-Chief, Indian Journal of Anaesthesia. [PDF]

Indian J Anaesth
Kurdi MS.
europepmc   +1 more source

Structural Insights Into the Function of Leishmania major Adenylosuccinate Lyase

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT One of several intriguing aspects of kinetoplastid biochemistry is the complete dependence on host purines and purine recycling due to the lack of a de novo purine biosynthesis pathway. Adenylosuccinate lyase (ASL, EC 4.3.2.2) is a key enzyme in the purine synthesis pathway responsible for the conversion of adenylosuccinate into adenosine ...
Ivan R. e Silva, Monique Mantovani, Maria E. S. D. Lino, Aline O. Albuquerque, João H. M. da Silva, Ronaldo A. P. Nagem, Adriana L. Rojas, Geraldo R. Sartori, Eduardo Horjales, David Campbell, Otavio H. Thiemann   +10 more
wiley   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Erratum: Zhang H, Liu Y, Yan Y, Qi J, Lin H, Jiang Y, Wang X, Cao H, Jiang Z, Zhang S, Wang T, Xu Y, Song W, Wang K, Zheng C, Zeng P. Unravelling the role of inflammatory markers in coronary artery disease risk via association, mediation and prediction analyses. J Glob Health. 2026;16:04060. [PDF]

J Glob Health
Journal of Global Health Editorial Team.
europepmc   +1 more source

Automated object detection based on YOLOv11 for monitoring benthic population dynamics: A new approach combining photogrammetry and open‐source GIS tools applied to sea cucumbers

Remote Sensing in Ecology and Conservation, EarlyView.
This research established a new object detection model based on YOLOv11 to recognise benthic organisms, specifically sea cucumbers, by utilising high‐resolution photogrammetric‐based orthomosaics acquired along infralittoral Mediterranean Sea beds. The model demonstrated impressive performance metrics and, when combined with the Deepness plugin for the
Gian Mario Sangiovanni, Giovanna Jona Lasinio, Daniele Poggio, Gianluca Mastrantonio, Alessio Pollice, Arnold Rakaj, Midhun Mohan, Stefano Moro, Edoardo Casoli, Daniele Ventura   +9 more
wiley   +1 more source

Supporting Local Scholarship for Equitable Representation in the National Health Science Journal. [PDF]

Acta Med Philipp
Sison-Aguilar AG.
europepmc   +1 more source

The Integration of AI, Blockchain and IoT for the Sustainable Development of the Logistics Service Industry: Insights From a PRISMA‐Based Analysis

Sustainable Development, EarlyView.
ABSTRACT This study presents an analysis of the literature on artificial intelligence (AI), blockchain and internet of things (IoT) for the sustainable development of the service industry of freight transport and logistics service providers (LSPs).
Roberto Cerchione, Renato Passaro, Matteo Tavano   +2 more
wiley   +1 more source

Toward an Effective Healthcare Workforce through Evidence-based Strategies. [PDF]

Acta Med Philipp
Sison-Aguilar AG.
europepmc   +1 more source