Results 51 to 60 of about 1,435,974 (238)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

Editor’s Note. Towards an Intelligent Society: Advances in Marketing and Neuroscience

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2019
This Special Issue focuses in cases that explore the relationship between Artificial Intelligence and marketing, as well as neuroscience. AI can be combined with specific neuroscience techniques to achieve a more successful and profitable neuromarketing.
Francisco Mochón   +1 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Editorial: Sweet sixteen [PDF]

open access: yes, 2018
This is the traditional triennial note used by the editors to give the readers of 4OR information on the state of the journal and its future. In the 3years that have passed since the last editorial note (Liberti et al.
Crama, Yves   +2 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

String Dualities and Toric Geometry: An Introduction [PDF]

open access: yes, 1998
This note is supposed to be an introduction to those concepts of toric geometry that are necessary to understand applications in the context of string and F-theory dualities.
Aspinwall   +31 more
core   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

IJIMAI Editor's Note - Vol. 5 Issue 3 - 10th Anniversary

open access: yesInternational Journal of Interactive Multimedia and Artificial Intelligence, 2018
The International Journal of Interactive Multimedia and Artificial Intelligence - IJIMAI (ISSN 1989 - 1660) provides an interdisciplinary forum in which scientists and professionals can share their research results and report new advances on AI tools or ...
Rubén González Crespo
doaj   +1 more source

Ethical Bedrock Under a Changing Negotiation Landscape [PDF]

open access: yes, 2017
Editors\u27 Note: Your dilemmas as a negotiator fall into two basic sets, “what’s possible?” and “what\u27s right?” The first is treated by many chapters in this book.
Gibson, Kevin
core   +1 more source

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