Expression of Concern: Uncertainty of future projections of species distributions in mountainous regions. [PDF]
PLOS One Editors.
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LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Expression of Concern: Inferring space from time: On the relationship between demography and environmental suitability in the desert plant O. rastrera. [PDF]
PLOS One Editors.
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Translating whole‐genome doubling into precision medicine in cancer
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley +1 more source
Expression of Concern: Effects of climate change on niche shifts of Pseudotrapelus dhofarensis and Pseudotrapelus jensvindumi (Reptilia: Agamidae) in Western Asia. [PDF]
PLOS One Editors.
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Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Expression of Concern: The fate of endemic insects of the Andean region under the effect of global warming. [PDF]
PLOS One Editors.
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Misinformation and trustworthiness: a meeting report on the 18th European Association of Science Editors General Assembly and Conference [PDF]
Jun-Beom Park, Cheol-Heui Yun
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This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu +3 more
wiley +1 more source

