Results 171 to 180 of about 5,237,043 (253)

A Large Outbreak of Gastrointestinal Infections Associated with <i>Escherichia coli</i> and Consumption of Milk Served in 25 schools in Toyama, Japan, June 2021. [PDF]

Food Saf (Tokyo)
Mizukami K, Noguchi N, Yahata Y, Tsuchihashi Y, Kurosaki K, Ohya K, Hirose S, Yoshinari T, Ohnishi T, Lee K, Iyoda S, Kusunoki H, Tsukada K, Yokota N, Kiritani A, Eino M, Nakada K, Raijou A, Hyakkoku Y, Edo T, Suzuki T, Takinami K, Akeda Y, Hara-Kudo Y, Sunagawa T.   +24 more
europepmc   +1 more source

β‐Adducin Restrains PLA2G4A‐Dependent Lysosomal Membrane Permeabilization and Neuronal Death in Ischemic Stroke

Advanced Science, EarlyView.
This study identifies β‐adducin as a regulator of lysosomal integrity in ischemic neurons. Ischemia‐associated FTO loss increases m6A modification and destabilizes Add2 mRNA, reducing β‐adducin expression and promoting PLA2G4A accumulation at lysosomes.
Hui‐qin Li, Pin‐yi Liu, Dan Wu, Fei‐yu Ma, Yi Bai, Sheng‐nan Xia, Hai‐yan Yang, Xin‐yu Bao, Yun Xu, Xiang Cao   +9 more
wiley   +1 more source

Relative abundance of Osteolaemus tetraspis in Uwa, Edumanom and Ogbe-Ijaw bushmeat markets in the Niger Delta region, Nigeria. [PDF]

BMC Zool
Ogorode IO, Ito EE, Oriakpono OE, Vincent-Akpu IF, Babatunde BB, Sikoki FD.   +5 more
europepmc   +1 more source

A Hypothalamic Oxytocinergic–Sympathetic Axis Couples Anxiety Dysregulation With Impaired Tendon–Bone Repair

Advanced Science, EarlyView.
RCI is associated with functional suppression of oxytocinergic neurons in the PVN. Reduced PVNOXT neuronal activity contributes to altered sympathetic regulation involving the IML–sympathetic chain pathway, accompanied by changes in norepinephrine signaling at the BTI.
Liyang Wan, Tingmo Huang, Liyue Zeng, Ruixue Du, Hengshuo Zhang, Shen Liu, Tao Zhang, Jianzhong Hu, Hongbin Lu   +8 more
wiley   +1 more source

A Biomimetic cRGDyk‐Engineered Platelet Nanoplatform for ACAD11 Delivery to Trigger Pyroptosis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
A biomimetic platelet nanoplatform (OE‐ACAD11@R‐PLT) is developed for targeted hepatocellular carcinoma immunotherapy. By selectively delivering therapeutic plasmids, this system induces mitochondrial dysfunction and triggers robust NLRP3/Caspase‐1/GSDMD‐mediated pyroptosis in tumor cells.
Hongyi Bao, Wei Feng, Wei Zong, Yi Li, Xinyue Qin, Xinyue Wang, Yubo Yang, Guanhua Chen, Yiting Hou, Xuan Tan, Lin Chen, Ming Zhang, Feng Wang   +12 more
wiley   +1 more source

Dual‐Dynamically Crosslinked Nanogels Enable Prolonged Ocular Retention for Multimodal Dry Eye Therapy

Advanced Science, EarlyView.
This berberine‐loaded dual‐dynamically crosslinked nanogel integrates tannic acid‐zinc metal‐phenolic networks and carboxymethyl chitosan/aldehyde‐functionalized poly(ethylene glycol) dynamic Schiff base networks, achieving 1‐year colloidal and antioxidant stability, sustained corneal berberine exposure for 24 h to support convenient once‐daily dosing,
Yanru Xin, Sisi Chen, Shengli Huang, Mengqi Huang, Jingyan Zhu, Zijian Wang, Jianliang Shen, Qinxiang Zheng   +7 more
wiley   +1 more source

Misleading inference of schistosome epidemiology from ribosomal internal transcribed spacer (ITS) and mitochondrial DNA. [PDF]

PLoS Pathog
Enabulele EE, Platt Ii RN, Adeyemi EE, Aisien MSO, Ajakaye OG, Ali MU, Amaechi EC, Atalabi TE, Auta T, Awosolu OB, Dagona AG, Edo-Taiwo O, Ejikeugwu CP, Igbeneghu C, Njom VS, Onwude-Agbugui M, Orji MN, Oyinloye FOP, Oyemade E, Ozemoka HJ, Pam CR, Ugah UI, Hulke JM, Arya GA, Anderson TJC.   +24 more
europepmc   +1 more source

Aged ZnO Nanoparticles Promote Breast Cancer Lung Metastasis by Remodeling the Pulmonary Microenvironment Through the CXCL10/Wnt/β‐Catenin Axis

Advanced Science, EarlyView.
In summary, pulmonary exposure to ZnO NPs, particularly aged NPs, promotes breast cancer metastasis by remodelling the lung tumour microenvironment. Aged ZnO NPs enrich M2‐macrophages, MDSCs and activated CAFs to form an immunosuppressive metastatic niche. CXCL10 from these cells drives metastasis via Wnt/β‐catenin activation.
Yong Zhu, Siyu Wang, Tong Lin, Jingyi Zhang, Jingya Yang, Dixiang Kang, Wenting Zhao, Na Yu, Meimei Wang   +8 more
wiley   +1 more source

Skyrmion Bubbles by Design in a Centrosymmetric Kagome Magnet

Advanced Science, EarlyView.
Chemical tuning of magnetocrystalline anisotropy in the centrosymmetric kagome magnet TmMn6Sn6 is shown to drive a spin reorientation transition via an intermediate magnetic fan state and to stabilize an emergent skyrmion bubble lattice. Four‐dimensional cryogenic Lorentz scanning transmission electron microscopy confirms the nanoscale texture ...
Mohamed El Gazzah, Fehmi Sami Yasin, Sk Jamaluddin, Hari Bhandari, Resham Babu Regmi, Xiuzhen Yu, Nirmal J. Ghimire   +6 more
wiley   +1 more source

Genomic epidemiology and evolutionary analysis of Lassa virus from small mammals suggest bidirectional viral movement across humans and animals. [PDF]

Virus Evol
Happi AN, Ogunsanya OA, Sijuwola AE, Saibu FM, Akano K, Ayinla AO, Daodu RO, Page B, Olumade TJ, Oguzie JU, Oluniyi PE, Adedokun OA, Fadele J, Nwofoke C, Elias OT, Ogundana KE, Lawal OZ, Nosamiefan I, Okolie J, Adelabu A, Lombardi K, Eller LA, Broach E, Prins PA, Heeney JL, Modjarrad K, Njatou TLFA, Parker ZF, McCauley M, Vasan S, Parker E, Collins ND, Michael NL, Happi CT.   +33 more
europepmc   +1 more source