Results 31 to 40 of about 5,237,043 (253)
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Chinese Medicine and Culture, 2018 Ben Cao Gang Mu (《本草纲目》 Compendium of Materia Medica) written by Li Shizhen (李时珍) was first introduced to Japan in the early 17th century and played an important role in the development of Japanese Material Medica and natural history in the Edo period ...
Min Zhou
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Dimensi: Journal of Architecture and Built Environment, 2003 In the early Edo period the number of memorial cloisters (tacchu) increased, especially, at Daitoku-ji and Myôshin-ji temples. As a consequence, the hondô (kyakuden, hojo) were further developed in all aspects of architectural style, interior design and ...
Antariksa Antariksa
doaj
Molecular Oncology, EarlyView.Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis +20 more
wiley +1 more source
Medical and Folklore Images during Pandemics: A Study of Edo Period Epidemic Visual Culture
Chinese Medicine and Culture. Edo-period historical records and documents preserved a substantial number of images, many of which are related to epidemic outbreaks. Through systematic collation and categorical analysis, this study uses the chronological and thematic characteristics
Yi ZENG, Yongzhi XIAO, Yang YANG
doaj +1 more source
Nihon Kikai Gakkai ronbunshu, 2014 The purpose of this paper is to clarify the factors which influenced the development of the technology in the Edo period. Especially, this paper tries to consider the influence on the mechanical technology development by the “Shinki-hatto”. “Shinki-hatto”
Yasuhiro KINOSHITA
doaj +1 more source
The Emotional Toll of Wartime Bell Deployment in Japan
Ars Orientalis, 2023 Buddhist temple bells (bonshō) are a precious feature of almost every Japanese temple. These bells often have a singular status within their environment, with a strong aural and visual presence prominently positioned in their own structure.
Sherry Fowler
doaj +2 more sources
FEBS Open Bio, EarlyView.TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose +9 more
wiley +1 more source