Introducing Borsantrazole: A Trifunctional Boron-Based Pyrazole That Extends the Lifespan of Amyotrophic Lateral Sclerosis Mice. [PDF]
Adv Sci (Weinh)Herein we report a boron‐based pyrazole, (Borsantrazole ‐ a small molecule that selectively targets oxidative stress) that significantly increases survival, reduces weight loss, delays disease onset, and affects global protein changes in the SOD1‐G37R mouse model of ALS.
Sanghai N +9 more
europepmc +2 more sources
Recent Advancements in Drug Delivery Across the Blood-Brain Barrier in Amyotrophic Lateral Sclerosis (ALS). [PDF]
CNS Neurosci TherProgressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Sanghai N +9 more
europepmc +2 more sources
Analysis of external dose rate attenuation and its related factors in differentiated thyroid carcinoma patients following I-131 therapy [PDF]
EJNMMI PhysicsBackground Monitoring the external dose rate (EDR) attenuation serves as a key consideration in supporting discharge decisions for patients with differentiated thyroid cancer (DTC) who have undergone radioiodine therapy.
Zimeng Sun +5 more
doaj +2 more sources
Beyond Single-Lead ECG-Derived Respiration Analysis: Use of Vectorcardiograms from the EASI-System for Breathing Frequency Estimation—A Feasibility Study [PDF]
SensorsPrecise respiration assessment is crucial for heart rate variability (HRV) interpretation as respiratory components—particularly respiratory sinus arrhythmia (RSA)—provide essential information on vagally mediated regulation.
Felix Maximillian Kuon +4 more
doaj +2 more sources
Sympathetic Response to Postural Perturbation in Stance
Frontiers in Human Neuroscience, 2021 The purpose of the present study was to elucidate whether the sympathetic response to perturbation in stance represents multiple mental responses, whether perturbation-induced fear of fall is one of the mental responses, and whether the sympathetic ...
Taku Kawasaki +4 more
doaj +1 more source
Energy and exergy investigations of r1234yf and R1234ze as R134a replacements in mechanically subcoo
Journal of Thermal Engineering, 2021 The aim of present work is the evaluation of mechanically subcooled simple vapour compression refrigeration system on the basis of energy and exergy analysis, and compatibility of alternative low GWP and zero ODP HFOs R1234yf and R1234ze to replace HFC ...
Shyam AGARWAL +2 more
doaj +1 more source
Determination Of Profitability With Non-Performing Financing As Moderation
JAS (Jurnal Akuntansi Syariah), 2022 This study aims to determine the effect of Capital Adequacy Ratio (CAR), Third Party Funds (TPF), and Islamicity Performance Index, which includes Profit Sharing Ratio (PSR), Zakat Performance Ratio (ZPR), and Equitable Distribution Ratio (EDR) on ...
Faiz Nasokha, Fetria Eka Yudiana
doaj +1 more source
Advanced techniques in the analysis of traffic accidents [PDF]
Glasnik Advokatske komore Vojvodine, 2023 Modern vehicles in road traffic are equipped with mutually integrated electronic devices used for managing systems. A chip in the airbag module identifies collisions and, at the same time, memorizes key parameters prepared for the analysis of traffic ...
Bodolo Ištvan
doaj
Model Order Reduction Technique Applied on Harmonic Analysis of a Submerged Vibrating Blade
International Journal of Applied Mechanics and Engineering, 2019 As part of an ongoing study into hydropower runner failure, a submerged, vibrating blade is investigated both experimentally and numerically. The numerical simulations performed are fully coupled acoustic-structural simulations in ANSYS Mechanical.
E. Tengs +3 more
doaj +1 more source
A Proposed New Endpoint Detection and Response With Image-Based Malware Detection System
IEEE Access, 2023 Due to increased reliance on technology and cloud-based services, cyber risks are more common. Advanced persistent threats make it difficult to detect attacks, hence Endpoint Detection and Response (EDR) was adopted in 2013.
Tran Hoang Hai +4 more
doaj +1 more source