Results 11 to 20 of about 943,880 (262)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ERA-EDTA Registry Annual Report 2018: a summary [PDF]

, 2020
Background: The ERA-EDTA Registry collects data on kidney replacement therapy (KRT) via national and regional renal registries in Europe and countries bordering the Mediterranean Sea.
Resić, Halima, Ots-rosenberg, Mai, Spustova, Viera, Beltrán, Palma, Finne, Patrik, Slon Roblero, María F, Golan, Eliezer, Garneata, Liliana, Roblero, María F. Slon, Kolesnyk, Mykola O., Gjorgjievski, Nikola, Kerschbaum, Julia, García, María Ángeles Palencia, Bazaga, Maria Angeles Garcia, Palsson, Runolfur, Lassalle, Mathilde, Santhakumaran, Shalini, Stel, Vianda S., Muñoz-Terol, José M, Farnés, Jordi Comas, Massy, Ziad A., Ten Dam, Marc A. G. J., Kolesnyk, Mykola O, Slon Roblero, Maria F., Boenink, Rianne, Bonthuis, Marjolein, Galvão, Ana A., Galvão, Ana A, Ioanou, Kyriakos, Arribas, Federico, Bell, Samira; id_orcid, Tomović, Filip, Comas Farnés, Jordi, Komissarov, Kirill, Santiuste de Pablos, Carmen, Ziginskiene, Edita, Jager, Kitty J., Zurriaga, Oscar, Muñoz-terol, José M., De Pablos, Carmen Santiuste, Andrusev, Anton, Winzeler, Rebecca, Idrizi, Alma, Garcia Bazaga, Maria Angeles, Stel, Vianda S, Vazelov, Evgueniy, Bell, Samira, Stendahl, Maria, Seyahi, Nurhan, Liliana, Garneata, Massy, Ziad A, Ten Dam, Marc A G J, Hommel, Kristine, Kuzema, Viktorija, Trujillo-Alemán, Sara, Åsberg, Anders, Kramer, Anneke, Jager, Kitty J, Lopot, František, Palencia García, María Ángeles, Ten Dam, Marc A.G.J., Magaz, Ángela   +61 more
core   +1 more source

EDTA-Functionalized Covalent Organic Framework for the Removal of Heavy-Metal Ions

, 2019
The removal of heavy-metal ions from wastewater has drawn intense attention, because of their toxicity, bioaccumulation tendency, and persistency in nature.
Chuanyao Liu (721937), Aisheng Huang, Yunzhe Jiang, Yunzhe Jiang (7297124), Aisheng Huang (1732360), Chuanyao Liu   +5 more
core   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Eficácia do EDTA 17% na difusão de íons cálcio e hidroxila através da dentina radicular de dentes decíduos – Análise in vitro. [PDF]

, 2012
TCC (graduação) - Universidade Federal de Santa Catarina. Centro de Ciências da Saúde. Odontologia.O propósito do presente estudo foi avaliar, in vitro, a eficácia do uso de EDTA 17% na difusão de íons cálcio e hidroxila através da dentina radicular de ...
Taguchi, Carolina Mayumi Cavalcanti
core  

EDTA-Derivatized Deoxythymidine as a Tool for Rapid Determination of Protein Binding Polarity to DNA by Intermolecular Paramagnetic Relaxation Enhancement

, 2016
EDTA-derivatized deoxythymidine (dT-EDTA), incorporated into DNA and complexed to Fe2+ in the presence of dithiothreitol, is a widely used reagent for sequence-specific cleavage of duplex DNA.
G. Marius Clore (237616), Junji Iwahara (1361682), Elizabeth C. Murphy (2992101), D. Eric Anderson (237592)   +3 more
core   +1 more source