Results 131 to 140 of about 2,664,245 (299)

Progress on the development of Class A GPCR‐biased ligands

open access: yesBritish Journal of Pharmacology, EarlyView.
Class A G protein‐coupled receptors (GPCRs) continue to garner interest for their essential roles in cell signalling and their importance as drug targets. Although numerous drugs in the clinic target these receptors, over 60% GPCRs remain unexploited. Moreover, the adverse effects triggered by the available unbiased GPCR modulators, limit their use and
Paula Morales   +20 more
wiley   +1 more source

Sex differences in the vasoactive effect of transient receptor potential channels: TRPM3 as a new therapeutic target for (neuro)vascular disorders

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Sex‐dependent vascular effects of transient receptor potential (TRP) channels and sex dimorphism in migraine are not yet fully characterized. We investigated the differential vasoactive effects of TRP ankyrin 1 (TRPA1), TRP melastatin 3 (TRPM3) and TRP vanilloid 1 (TRPV1) channels, their pharmacological mechanism(s), and
Eduardo Rivera‐Mancilla   +7 more
wiley   +1 more source

The Socialization of Cultural Values and the Development of Latin American Prosociality

open access: yesChild Development Perspectives, EarlyView.
ABSTRACT Understanding childhood socialization across multiple world cultures is important for developing comprehensive and generalizable theories of developmental psychology. Studies suggest that Latin American children show markedly high levels of prosocial behavior.
Rodolfo Cortes Barragan   +1 more
wiley   +1 more source

Between surveillance and self‐surveillance: What institutionalised girls in Ciudad Juárez (reveal that they) know about sexuality

open access: yesChildren &Society, EarlyView.
Abstract We describe how girls aged 7 to 12 from social care homes in Ciudad Juárez (Mexico) talk about sexuality in workshops that we led, focusing on how mechanisms of surveillance and self‐surveillance operate in a context in which the research framework opens up new norms for socially acceptable ways of talking about sexuality.
Bruna Alvarez   +3 more
wiley   +1 more source

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