Results 131 to 140 of about 21,060,376 (300)
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Tuning Journal for Higher Education, 2014 Editorial Team Tuning Journal for Higher Education
doaj +4 more sources
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A Conversation on Artificial Intelligence, Chatbots, and Plagiarism in Higher Education
Cellular and Molecular Bioengineering, 2023 Michael R. King, chatGPT
semanticscholar +1 more source
The Digital Revolution and Higher Education [PDF]
, 2011 Presents survey findings about the views of college presidents and the public on the value of, prevalence of, and experience with online learning, as well as the role of the Internet and related technologies in education and prospects for future ...
Amanda Lenhart +2 more
core
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
O ensino de enfermagem sobre HIV/ Aids sob a ótica da cidadania
Revista Gaúcha de EnfermagemO objetivo foi verificar a percepção de docentes de Enfermagem sobre sua responsabilidade na prática pedagógica em HIV/Aids e se valorizam a construção do conhecimento sobre a temática do HIV/Aids centrado nos parâmetros voltados à cidadania.
Simone de Oliveira Camillo +2 more
doaj
Investigation of Workload Control Methods for Shops with Re-Entrant Flows
Management Systems in Production EngineeringThe re-entrant flow with an unpredictable nature of arrival would apparently harm production plans and schedules in flow type of shops. The re-entrant flow with varied arrival frequencies in rotor blade manufacturing is quite complicated and results in ...
Prabhu Aruna +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source