Results 41 to 50 of about 3,730,399 (282)

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

open access: yesMolecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto   +13 more
wiley   +1 more source

Designing English Coursebook for Islamic Bilingual Boarding School Based on the Value of the Four Pillars of Nationality

open access: yesJurnal Kependidikan, 2021
The purpose of this study is to develop an English course book for bilingual boarding school (Pesantren). The value of four of national pillars (Pancasila, Bhineka Tunggal Ika, UUD 45 and NKRI) is chosen as the theme of the course book.
Mahmud Mahmud, Linda Linda
doaj   +1 more source

Poetry and Moral Education in Teaching Learning Literature [PDF]

open access: yes, 2015
In teaching learning literature, students are not only given by the materials which have the cognitive aspect but also they need to be given education which is related to the values of morale which can be utilized in their life.
Widyahening, C. E. (Ch)
core  

Centre for Applied Linguistics at the University of Warwick [PDF]

open access: yes, 2008
The Centre for Applied Linguistics was established in 1983 and has grown from a relatively small teaching unit to a large centre engaged in a wide variety of activities under the broad heading of Applied Linguistics.
Farida, Nevin   +3 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

Enhancing Environmental Awareness and Scientific Behaviour through Buried Compost Bin Media

open access: yesProfesi Pendidikan Dasar
The educational system faces an epistemological dilemma stemming from individuals’ limited ability to manage their own waste. The integration of the Pancasila Student Profile Strengthening Project into primary school curricula through the use of Buried ...
Aliet Noorhayati Sutisno   +3 more
doaj   +1 more source

Excellence in teaching and learning: A review of the literature for the Higher Education Academy [PDF]

open access: yes, 2007
The Higher Education Academy commissioned a review of the literature on excellence in learning and teaching in higher education to enhance the higher education sector’s understanding of the varied conceptualisations and usages of the term ‘excellence ...
Little, Brenda   +3 more
core  

Core professionalism education in surgery: A systematic review [PDF]

open access: yes, 2018
Background: Professionalism education is one of the major elements of surgical residency education. Aims: To evaluate the studies on core professionalism education programs in surgical professionalism education. Study Design: Systematic review.
Büke, Akile Sarıoğlu   +3 more
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

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