Results 41 to 50 of about 4,813,232 (331)

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

A white paper from the FEBS Education and Training Conference: challenges, opportunities, and action plans for transforming molecular life sciences education

FEBS Open Bio
The inaugural FEBS Education and Training Conference (ETC) was held in Türkiye, in 2024. This first‐ever Molecular Life Sciences Education Conference in Europe was organized by the FEBS Education and Training Committee and it was a groundbreaking event ...
Ly Villo, Nino Sincic, Luciane V. Mello, Manuel Joao Costa, Didier Picard, Francesco Malatesta, Jerka Dumic, Ferhan G. Sagin   +7 more
doaj   +1 more source

Gender-based and grade-level mapping of student genetic literacy in the midst of the covid-19 pandemic

Biosfer, 2022
The Covid-19 pandemic has resulted in the face-to-face teaching and learning process being shifted to distance learning which has the potential to affect student literacy levels.
Alvin Dewa Yanuar, Sri Wahyuni, Diani Fatmawati, H Husamah, Lud Waluyo, Ahmad Fauzi   +5 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Branding and Digital Marketing Innovation for Siwang MSMEs Empowerment in Indramayu West Java

Jurnal Pengabdian UNDIKMA
This community service aims to enhance the branding capacity and digital marketing competencies of “Siwang”, a traditional shrimp-paste-based MSME in Gantar Subdistrict, Indramayu Regency. The intervention employed a participatory approach, encompassing
Fitra Jaya, Yati Yati, Sucipto Sucipto, Romi Siswanto, Kadarisman Kadarisman, Gayatria Oktalina, Agnisa Widayanti   +6 more
doaj   +1 more source

Edmodo as a solution to enhance student learning interest in high school biodiversity during the COVID-19 pandemic

Biosfer, 2020
This study aims to improve the quality of learning by applying Edmodo's application at biodiversity class material of class 10 students in increasing student learning interest during Covid-19 period.
Ervan Johan Wicaksana, Pramana Atmadja, W Wikanso, Loly Nadila Putri, Gusti Ayu Muthia   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Peer Learning Has Double Effects in Clinical Research Education: A Qualitative Study

International Journal of Pediatrics
Background. Peer learning has been recognized for its effectiveness in health professional education. However, its effects on clinical research education are not clear and were explored qualitatively in this study. Methods.
Hiro Nakao, Osamu Nomura, Chie Nagata, Akira Ishiguro   +3 more
doaj   +1 more source