Results 131 to 140 of about 272,670 (303)
Advanced Science, EarlyView.SLC2A3 derived lactate promotes metastasis through p53 lactylation at K120 and osteoclast differentiation. Pharmacological inhibition of SLC2A3 upregulates PD‐1 expression on CD8+ T cells via lactate induced p53 lactylation, which modulates immune evasion. ABSTRACT Bone metastasis is a devastating consequence of lung cancer.
Yi Ding +10 more
wiley +1 more source
Advanced Science, EarlyView.Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel +12 more
wiley +1 more source
Macroeconomic imbalances. Country Report: Spain 2015 [PDF]
, 2015 Directorate-General for Economic and Financial Affairs (European Commission)
core +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source
Alphaviral Capsid Proteins Inhibit Stress Granule Assembly via Competitive RNA Binding With G3BP1
Advanced Science, EarlyView.Stress granules exert antiviral functions. This study illustrates a conserved function of alphaviral capsid proteins in modulating stress granules. Oligomerization mediated by a helical motif coupled with a positively charged intrinsically disordered region (IDR) directly competes with G3BP1 for RNA binding, thereby disrupting G3BP1‐RNA liquid–liquid ...
Yun Zhang +10 more
wiley +1 more source
The impacts of non traditional exports on income, child health and education in rural Zambia
Económica, 2008 This paper investigates the impacts of non-traditional exports on household outcomes in rural Zambia. It is the attempt to identify and estimate second round effects that distinguishes this paper from most of the current literature. We study the impacts
Jorge Balat
doaj
Delivery of Pleckstrin‐Homology Domains Suppresses PI3K/Akt Signaling and Breast Cancer Metastasis
Advanced Science, EarlyView.Current therapies curb tumor growth but not metastasis. Obscurin, a giant metastasis suppressor lost in breast cancer, restrains PI3K/Akt signaling but is impractical to restore. We deploy a mini‐obscurin, comprising the obscurin‐PH‐domain, which sequesters PI3K‐p85, potently suppressing invasion and metastasis.
Matthew Eason +12 more
wiley +1 more source
Marketization of data elements drives the cultivation of competitive advantages in export products-Based on an export technology complexity perspective. [PDF]
PLoS OneLin K, Wang X.
europepmc +1 more source
MAIN EXPORT DIRECTIONS OF EDUCATION SERVICES
Высшее образование в России, 2016 He article describes the main directions of educational services export, discusses the questions of foreign citizens' education expediency from the point of view of the state and university. The article also reveals the reasons why foreign citizens desire to be trained at higher education institutions of Russia. The main directions of the international
openaire +1 more source