Results 91 to 100 of about 2,293,576 (293)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Appointments to General Education Coordinating Committee [PDF]

open access: yes, 1980
Accepted by President Albert Brown- 05/22/80Resolution Number: 1979-1980_33Academic Year: 1979-1980Appointments to the General Education Coordinating Committee include: Grace Alvarez-Altman, Frederick Burelbach, Robert Cassie, Charles Edwards, and John ...
General Education Curriculum and Policies
core  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Stress and coping strategies used by special education and general classroom teachers [PDF]

open access: yes, 2018
This research was undertaken to shed light on sources of stress, effects and coping strategies used by general (mainstream) classroom teachers and special education teachers.
Al-Hroub, Anies, Kebbi, Marwa
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

General Education: Second Semester Foreign Language Proposal [PDF]

open access: yes, 2006
Received and Acknowledged 5/16/06 - Effective 5/16/06Resolution Number: 2005-2006_32Academic Year: 2005-2006All students entering SUNY Brockport in the Fall 2006 semester are required to take two semesters of a foreign language for the General Education ...
General Education Curriculum and Policies
core  

Usability of ChatGPT in the english essay writing proficiency of the BEED students

open access: yesJournal of Science and Education
The advancement of AI technology, especially in language processing systems like ChatGPT, creates opportunities for students to elevate their writing skills.
Karl Alvin Aglibot   +5 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Annual Report, General Education Committee, 2008-2009 [PDF]

open access: yes, 2012
The 2008-2009 academic year annual report from the General Education Committee, a committee under the University of South Florida St.
General Education Committee   +1 more
core  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

open access: yesFEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli   +8 more
wiley   +1 more source

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