Results 51 to 60 of about 2,283,489 (313)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Addressing workplace harassment: a multifaceted approach for nursing students in a tertiary hospital in Singapore

open access: yesBMJ Open Quality
Methods Interventions included the development and dissemination of infographic booklets, the establishment of CAPES Buddy for incident reporting and faculty training in psychological support skills.
Manpreet Kaur   +5 more
doaj   +1 more source

Discipline-based Art Education and the Viability of Introducing It, through General Education, in the Kingdom of Saudi Arabia [PDF]

open access: yesJournal of Islamic Studies, 2004
The research is one of the very few works that deal with this theory in Arabic. This is one of the most important (if not the most important) of all theories in the realm of art education.
Mohamed Hussein A. Aldoyhi
doaj  

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

open access: yesMolecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos   +6 more
wiley   +1 more source

Challenges of General Practice Education in Iran: A Qualitative Study [PDF]

open access: yesStrides in Development of Medical Education, 2013
Background & Objective: According to some evidences medical graduates do not evaluate their skills and capabilities to perform professional responsibilities at an acceptable level In other words there is a disagreement among authorities and experts of ...
Mohammadreza Amiresmaili   +3 more
doaj  

Development of type 2 diabetes mellitus quality indicators in general practice by a modified Delphi method in Beijing, China

open access: yesBMC Family Practice, 2020
Background The service capacity of primary care has improved in China. General practice also takes growing responsibility in the management of type 2 diabetes mellitus, but there are concerns about the paucity of evidence of the quality of care delivered.
Guanghui Jin   +8 more
doaj   +1 more source

General Education Committee Annual reports

open access: yes, 2017
New reports are added annually.See also the General Education Committee meeting minutes at: https://soar.wichita.edu/handle/10057/21766Reviews of Student Learning Outcomes (SLO) issued annually by Wichita State University Faculty Senate General Education
Faculty Senate. General Education Committee
core  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

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