Results 91 to 100 of about 4,685,155 (297)

Effect of Industry 4.0 on Education Systems: An Outlook [PDF]

, 2018
Congreso Universitario de Innovación Educativa En las Enseñanzas Técnicas, CUIEET (26º.
López Brugos, José Antonio, Ponte Blanco, Borja, Rosillo Camblor, Rafael, Álvarez Gil, Nicolás   +3 more
core  

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Universalisation de l’éducation en Uruguay : les droits en question

Revue Internationale d’Éducation de Sèvres, 2022
Nilia Viscardi Etchart
doaj   +1 more source

Barriers and beliefs: a comparative case study of how university educators understand the datafication of higher education systems. [PDF]

Int J Educ Technol High Educ, 2023
Stewart B, Miklas E, Szcyrek S, Le T.
europepmc   +1 more source

Trade and Divergence in Education Systems [PDF]

This paper presents a theory on the endogenous choice of a country's education policy and the two-way causal relationship between trade and education systems.
Fali Huang, Pao-Li Chang
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

République tchèque : une décennie de réformes et de projets

Revue Internationale d’Éducation de Sèvres, 2023
Tomáš Klinka
doaj   +1 more source

Understanding teachers’ working experiences: capturing data on teachers as professionals, learners and change-makers in low resource contexts [PDF]

, 2017
When we picture a school, many of us will see a teacher, standing at the front of a classroom. When our children are at school, it’s their teachers we turn to with concerns.
Addae-Kyeremeh, Eric, Buckler, Alison, High, Chris, Moore, Rhiannon, Rossiter, Jack, Singh, Renu   +5 more
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source