Results 91 to 100 of about 1,330,224 (318)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

TechMIS Newsletter (October 2001) [PDF]

, 2000
The October 2001 newsletter included a memorandum to subscribers from Charles Blaschke, a Washington Update, a special report on Estimated Expenditures of Federal and State Funds on Education Technology Products and Services During School Year 2001-2002,
Education Turnkey Systems
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Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

TechMIS Special Report (February 2004) [PDF]

, 2004
This February 2004 Special Report includes two different reports. The first is on the FY 2004 Federal Education Budget and the proposed FY 2005 Budget from the administration.
Education Turnkey Systems
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Slovenian Education in the Gorizia Region During the Transition from Austria-Hungary to Italy [PDF]

Šolska Kronika
The article discusses the development and challenges of the Slovenian school system in the Gorizia region during the transition from Austria-Hungary to Italy after World War I.
Robert Devetak
doaj  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

TechMIS Newsletter (March 2001) [PDF]

, 2000
The March 2001 newsletter included a memorandum to subscribers from Charles Blaschke, a Washington Update, special reports on the proposed FY 2002 Budget and Title I, and a press release about TURNKEY seeking Vendor Sponsors of Survey on Technology Use ...
Education Turnkey Systems
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On Evaluating Adaptive Systems for Education

, 2002
In this paper we have gathered some interesting techniques to evaluate educative systems. Our main purpose is to evaluate HEZINET, an adaptive hypermedia system for education available commercially. Therefore, we also include a system evaluation plan to identify which types and techniques of evaluation will be needed in order to accomplish it.
Gutierrez Serrano, Julian, Arrubarrena Santos, Rosa, Perez Fernandez, Tomas Antonio, Lopez Cuadrado, Javier, Vadillo Zorita, Jose Angel   +4 more
openaire   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

TechMIS Newsletter (April 2017) [PDF]

, 2017
The April 2017 newsletter is the final one for subscribers and includes a memorandum from Charles Blaschke and Dr. Suzanne Thouvenelle; a special report on major concerns of the Council of Great City Schools (CGCS) about the Administration’s education ...
Education Turnkey Systems
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