Results 121 to 130 of about 1,079,892 (268)

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

open access: yesMolecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant   +7 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

open access: yesMolecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi   +6 more
wiley   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

Inde : un nouveau paysage éducatif

open access: yesRevue Internationale d’Éducation de Sèvres, 2017
Padma M. Sarangapani
doaj   +1 more source

Politique d’éducation et évolution de l’école en Autriche

open access: yesRevue Internationale d’Éducation de Sèvres, 2020
Karl Heinz Gruber
doaj   +1 more source

Exclusion and neoliberalism in the education system: socio-educational intervention strategies for an inclusive education system

open access: yes, 2018
Not only numerous academic and empirical studies recognise the educational factor as decisive on life and work trajectories, but also its integrating potential and role in the promotion of social cohesion are widely acknowledged. The diversity of current societies, the economic situation and the impact of neoliberal policies represent new challenges ...
Martínez Virto, Lucía   +1 more
openaire   +3 more sources

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

Le système de formation des ressources humaines en Tunisie

open access: yesRevue Internationale d’Éducation de Sèvres, 2017
Mohamed Adel Ben Amor, Mlaoueh Ammar
doaj   +1 more source

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