Results 241 to 250 of about 4,685,155 (297)

Advances in the application of artificial intelligence in ophthalmic education and clinical training. [PDF]

Front Med (Lausanne)
Chi M, Cui Y, Xi L.
europepmc   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Global landscape and professionalization of infection preventionist education: comparative insights and future directions. [PDF]

Front Public Health
Cao YL, Shan J, Bao XY, Jin M, Huai W, Jin YC, Jin YX, Zhang ZX, Kuang JQ.   +8 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

The Promise, Pitfalls, and Practicalities of Precision Education in Obstetrics and Gynecology. [PDF]

O G Open
Baecher-Lind L, Stephenson-Famy A, Chen KT, Fleming A, Kim C, Patel S, Schaffir J, Sims SM, Sonn T, Sutton JM, Saint Louis H.   +10 more
europepmc   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Advancing Global Nursing Policy: AI-Driven Health Literacy Innovations for Migrant Domestic Workers. [PDF]

Int Nurs Rev
Cheong PL, Kubota K.
europepmc   +1 more source

Reimagining medical education: integrating medical humanism and narrative medicine into a new educational paradigm. [PDF]

Front Med (Lausanne)
Hou Z, Chen J, Guo H.
europepmc   +1 more source

From policy to practice: why the WHO's Africa rehabilitation strategy 2025-2035 risks failure without educational reform. [PDF]

Front Med (Lausanne)
Npochinto Moumeni I.
europepmc   +1 more source