Results 41 to 50 of about 4,964,387 (262)

The Impact of Organizational Trust on Organizational Commitment Through the Mediating Variable of Organizational Participation [PDF]

پژوهش‌های مدیریت عمومی, 2019
The objective of the present study was to examine the impact of organizational trust on organizational commitment through the mediating variable of organizational participation. This descriptive-correlational study followed a correlation design.
MohebAli Dahmardeh, Naser Nastiezaie
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Explanation of the Role of Ethical Climate & Social Undermining in Employee Job Involvement [PDF]

International Journal of Ethics and Society, 2021
Background: Job involvement is one of the most important ways to increase employee effectiveness by improving ethical climate and reducing social undermining. On the other hand, job involvement helps employees to be more committed to their work.
Asad Yeganeh, Faranak Mosavi, Elham Kaveiani, Sahar Mohammadi   +3 more
doaj  

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Motivations for Studying in Saudi Arabia

المجلة الدولية للعلوم الإنسانية والاجتماعية
The number of international students enrolling in higher education institutions is steadily increasing each year, including in Saudi Arabia. This study aimed to explore the motivations behind international students' decisions to attend public ...
Dr. Saud G Albeshir, Ali Ahmed Matar, Ayoub Ibrahim Lahcen Waali, Driton Ramush Lekaj, Ervis Abdyl Sulaj, Ilboudo Loukman Ishake, Ouattara Karim, Siaka Ouedraogo   +7 more
doaj   +1 more source

Designing and validating professional Capabilities Model of Talented Faculty Members at Comprehensive Universities with Regional Performance level [PDF]

Pizhūhish dar Āmūzish-i ̒ulūm-i Pizishkī, 2019
Introduction: Today, due to the dynamic environmental changes, higher education system, like other systems, requires change. Given the role of faculty members in the quality development of provided services by the university, identification the required ...
Y Roumiani, Kh Abili, J Pourkarimi, S Farahbakhsh   +3 more
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Validation of academic organizational capacity framework [PDF]

فرایند مدیریت و توسعه
Purpose: The purpose of this study was to validate the academic organizational capacity framework from the perspective of the presidents of public universities in the country.
Jafar Torkzadeh, Fatemeh Zeinali, Zahra Pakbaz   +2 more
doaj