Results 181 to 190 of about 616,427 (267)

EUFOREA summit in Brussels 2025: inspiring the future of allergy and respiratory care. [PDF]

Front Allergy
Lau S, Backer V, Scadding GK, Barnes PJ, Bernal Sprekelsen M, Bertels X, Blaiss M, Borzova E, Brüggen MC, Cardell LO, Conti DM, Cornet M, De Corso E, Djukanovic R, Fokkens WJ, Fox AT, Gaga M, Gevaert P, Gibson P, Gray CL, Heaney LG, Heffler E, Hoffmann HJ, Hopkins C, Jackson D, Jesenak M, Johansen P, Khaleva E, Lee S, Mäkelä MJ, Melén E, Mullol J, Nieto A, Pavord I, Peters A, Price D, Quirce S, Ryan D, Schneider S, Senior B, Shire CME, Smith P, Teeling T, Virchow JC, Lund V, Wahn U, Hellings PW.   +46 more
europepmc   +1 more source

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

A practice-embedded, PDSA-guided implementation study of continuing professional development for stoma care in a resource-constrained setting. [PDF]

Front Med (Lausanne)
Bi R, Zhao H, Tang L, Zhou R, Liu L.
europepmc   +1 more source

N4‐acetylcytidine in LncRNA Gm26917 Promotes Translation in Female Germline Stem Cells by Recruiting Ribosomal Protein mRNA via EEF1A1

Advanced Science, EarlyView.
This work establishes that ac4C modification on lncRNA Gm26917 governs its spatial interactions with Rpl10 mRNA, and RBP EEF1A1 mediates the interaction between Gm26917 and Rpl10. It elucidates a novel ac4C‐Gm26917‐EEF1A1‐Rpl10 axis in FGSC maintenance both in vitro and in vivo, and provides a potential molecular target for modulating germ cell ...
Xinyue Li, Xiaopeng Hu, Ji Wu
wiley   +1 more source

Beyond social media: the era of generative AI and intelligent digital platforms in nephrology education. [PDF]

Ren Fail
Cheungpasitporn W, Pesce F, Thongprayoon C, Miao J, Baloch MY, Soliman K, Chávez Iñiguez JS.   +6 more
europepmc   +1 more source

A NeuroD1 AAV‐Based Gene Therapy for Functional Brain Repair in Alzheimer's Disease‐Like Non‐Human Primate Model

Advanced Science, EarlyView.
This study tests NeuroD1 AAV‐based gene therapy in a non‐human primate Alzheimer's disease model. The therapy prevents neuronal damage, inhibits hippocampal atrophy, and reduces neuroinflammation. It also repairs vascular and blood‐brain barrier damage, restores cerebrospinal fluid biomarkers, enhances hippocampal glucose metabolism, and improves ...
Zhouquan Jiang, Yongpeng Qin, Bin Luo, Fan Bai, Jiangyue Liu, Long Ma, Shu He, Rongjie Chen, Yuchen Wang, Shanggong Liu, Ying Sun, Yi Chen, Shuo Zhang, Jiaqi Liang, Feng Liao, Huiyi Wei, Junjie Wei, Lu Wang, Hao Xu, Zheng Wu, Gong Chen, Wenliang Lei   +21 more
wiley   +1 more source

Editorial: Multidimensional approaches to suicide prevention: innovations, challenges, and future directions. [PDF]

Front Public Health
Fernández-Jiménez E, Kelley A.
europepmc   +1 more source

NUDT21 Drives T‐Cell Acute Lymphoblastic Leukemia Through Dual Regulation of Alternative Polyadenylation and Transcriptional Activation

Advanced Science, EarlyView.
In summary, our study defines a coordinated oncogenic model in which NUDT21 integrates alternative polyadenylation–dependent UBE2D3 stabilization and transcriptional activation to sustain MYC‐driven T‐ALL cell survival, thereby establishing NUDT21 as a central regulatory node and a promising therapeutic target.
Conglian Qiu, Jianwei Wang, Zhiheng Li, Qi Ji, Hui Zhang, Qinyi Zhang, Senlin Zhang, Juanjuan Yu, Yanfang Tao, Yijun Wu, Chunxia Shi, Zong Zai, Zimu Zhang, Yizhen Li, Zhenjiang Bai, Shaoyan Hu, Jian Pan, Yang Yang, Shuiyan Wu   +18 more
wiley   +1 more source

Gender differences in diabetes knowledge, glycemic control, and cardiovascular risk among adults with type 2 diabetes: a cross-sectional study. [PDF]

Front Endocrinol (Lausanne)
Albasheer O, Mahfouz MS, Alssum A, Majrashi M, Hamdi A, Alhazmi WM, Hakami BH, Awaf AA, Hassan R, Rajeh N, Solan T, Madkhali T, Alessa H, Madkhali A, Hakami A.   +14 more
europepmc   +1 more source