Results 211 to 220 of about 614,793 (319)

Diagnostic performance of two commercially available, PPG-based smartphone applications to detect atrial fibrillation. [PDF]

Eur Heart J Digit Health
Szonyi MD, Gausz FD, Bocz B, Pilecky D, Muk B, Banfi-Bacsardi F, Foldesi C, Andreka P, Szili-Torok T, Kupo P, Vamos M.   +10 more
europepmc   +1 more source

Liver Stiffness Directs Intrahepatic Cholesterol Accumulation Through YAP/TAZ in Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
Liver stiffness promotes intrahepatic cholesterol accumulation by repressing LXRα through YAP/TAZ activation. Stiff matrices impair cholesterol efflux in hepatocytes, while YAP/TAZ deletion restores LXRα activity and prevents cholesterol‐induced fibrosis.
Na Young Lee, Myeung Gi Choi, Ho Jae Ryu, Young Jin Min, Seon Min Kim, Yeonseok Chung, Bo Kyung Koo, Yun Pyo Kang, Won Kim, Ja Hyun Koo   +9 more
wiley   +1 more source

Editorial: Exploring life skills and positive youth development through sports. [PDF]

Front Sports Act Living
Muñoz-Llerena A, Hernández-Hernández E, Murta L, Lagunes-Carrasco JO.   +3 more
europepmc   +1 more source

Berne-Knox-Westerlo Central School District and Berne-Knox-Westerlo Teachers Association, NYSUT, Local 2501 (1993) [PDF]

, 1993

core   +1 more source

Chronic Hypoxia Disrupts Spermatogenesis Through ASXL2–EZH2–Mediated Microtubule Destabilization

Advanced Science, EarlyView.
This study reveals the mechanism by which chronic hypoxia impairs spermatogenesis via the ASXL2–EZH2 axis, hindering the transition of spermatids from round to elongated forms. Key findings reveal that under hypoxic conditions, downregulated ASXL2 expression reduces EZH2 binding to the CEP162 promoter, leading to decreased H3K27me3 modification and ...
Jun Yin, Mengjie Zhang, Wenying Liu, Wenlong Shen, Debao Li, Hongming Miao, Fang Deng, Gang Zhang, Yi Tian, Yi Zhang, Zhihu Zhao, Bing Ni   +11 more
wiley   +1 more source

Healthy food and dietary patterns: a cross-sectional study in Riyadh, Saudi Arabia. [PDF]

Front Public Health
Alhusseini N, Sajjad M, Rahman H, Naimi H, Jamal M, Raziq T, Khan Z, Raddawi SF, Raddaoui L, Omair A, AlNasser SK, Alsouss YO, Tamim H, Ateq K.   +13 more
europepmc   +1 more source

Mitochondrial Calcium Uniporter Drives Chemoresistance in Pancreatic Cancer via Glutathione‐Mediated Stemness Maintenance

Advanced Science, EarlyView.
PDAC has a poor prognosis due to chemoresistance. We revealed that MCU upregulation is associated with chemoresistance and stemness in PDAC. MCU‐mediated Ca2+ influx induced ER stress, activating the PERK‐ATF4/NRF2 axis to enhance PSAT1/SLC711 expression and glutathione synthesis, reducing ROS and maintaining stemness.
Zekun Li, Chenyang Meng, Guangcong Shen, Yueying Shan, Junjin Wang, Diliyaer Abudukeremu, Rui Zhao, Bo Ni, Chao Xu, Xiaofan Guo, Jun Yu, Kaiyuan Wang, Shengyu Yang, YunZhan Li, Yongjie Xie, Tianxing Zhou, Jihui Hao, Xiuchao Wang   +17 more
wiley   +1 more source

Associations of serum creatinine and blood urea nitrogen with depressive symptoms among community-dwelling older adults in Guangzhou, China: a cross-sectional study. [PDF]

Front Psychiatry
Huang J, Fu Y, Fu Y, Pan Y, Hu Y, Zhang J, Guo W, Du X.   +7 more
europepmc   +1 more source

Thermal Plasticity is Regulated by a Key MicroRNA During Range Expansion of an Invasive Fruit Fly

Advanced Science, EarlyView.
Populations at the invasion front of Bactrocera dorsalis adapt through reduced phenotypic and gene expression plasticity, a phenomenon likely to be driven by genetic assimilation. We identify a key miRNA‐mediated regulatory axis, in which miR‐276b post‐transcriptionally represses thw, a conserved chitin‐binding gene critical to the cold‐tolerance ...
Yan Zhao, Juntao Hu, Juan Du, Shaokun Guo, Youming Hou, Zhihong Li   +5 more
wiley   +1 more source