Results 241 to 250 of about 145,748 (333)

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Parental knowledge and awareness of complications of recurrent adenotonsillitis and its surgical management in children in the Jazan region, Saudi Arabia: a cross-sectional study. [PDF]

Front Pediatr
Otaif AA, Dighriri RM, Otaif AA, Jahlan RA, Alotayf OA, Shaikh AY, Alwadani SN, Alnami RM, Soweedi AM.   +8 more
europepmc   +1 more source

A Biomimetic Nanoparticle System Intercepts and Degrades Thrombospondin‐1 to Restore Vascular Homeostasis After Ischemic Injury

Advanced Science, EarlyView.
TAX2‐NPs capture extracellular TSP‐1 in the injured liver and promote its macrophage‐mediated autophagic degradation. This process blocks TSP‐1/CD47 signaling, restores VEGFR2‐AKT activity, preserves endothelial function, and mitigates hepatic ischemia‐reperfusion injury.
Haorui Wang, Xiandi Meng, Yanbao Xin, Kuirong Mao, Huizhu Tan, Changkai Ma, Xiuxiu Cong, Mengfei Zhao, Meiling Yu, Si Chen, Yue Hou, Yong‐Guang Yang, Tianmeng Sun   +12 more
wiley   +1 more source

Discovery of a Potent Fluorescence Polarization Probe for Identifying USP1 Allosteric Inhibitors

Advanced Science, EarlyView.
This study presents the first ubiquitin‐specific protease 1 (USP1) allosteric fluoroprobe and fluorescence polarization assay, enabling the differentiation of allosteric and catalytic site inhibitors. Further, a novel class of tetrahydroisoquinoline‐based USP1 inhibitors is designed, with compound 14a (USP1 IC50 = 29.9 nM) showing strong selectivity ...
Jiawei Cheng, Peipei Wang, Pengfei Wang, Jiamin Wang, Baiyang Li, Daqing Fang, Jian He, Xiaobei Hu, Weijuan Kan, Yubo Zhou, Chunpu Li, Jia Li, Hong Liu   +12 more
wiley   +1 more source

Impact of educational intervention on the uptake of self-sampling for HPV test-based cervical cancer screening. [PDF]

Front Oncol
Akintola A, Dareng EO, Adebamowo SN, ACCME Research Group as part of the H3Africa Consortium , Adebamowo CA.   +4 more
europepmc   +1 more source

A Crack‐Based One‐Dimensional Microspheres Array Enables Thermal–Mechanical Decoupled Dual‐Functional Sensing

Advanced Science, EarlyView.
Inspired by Nostoc, a crack‐based one‐dimensional microspheres array (COMA) sensor is developed, which stabilizes crack geometry under isotropic expansion, enabling a predictable, monotonic thermal response from which true strain can be accurately extracted. The COMA sensor exhibits high sensitivity at ultralow deformation (gauge factor up to 89) and a
Wanqing Xu, Hongyi Tu, Zehao Wang, Tianyu Zhu, Chao Wang, Min Chen, Lan Shi, Limin Wu   +7 more
wiley   +1 more source

Application of artificial intelligence in medical education: Saudi Arabian perspective. [PDF]

Front Med (Lausanne)
Al-Jehani H, Mousa AH, Albulaihed S.
europepmc   +1 more source

An analysis of graduate theses in the Master of Arts in Education Major in Administration and Supervision

International Journal of Research Studies in Management
Luis I Gante Jr., Felino B Javines Jr., Jenny A Galay-Limos, Neofe J Lazaro   +3 more
openaire   +1 more source

Reaction‐Induced Reversible Reconstruction Enhanced Ni‐MgO/CaO Dual Functional Material for Stable CO2 Capture and In Situ Conversion

Advanced Science, EarlyView.
A highly dispersed NiO‐MgO solid solution (MgxNi1‐xO) is created in a hierarchically porous Ca‐based matrix to protect Ni and CaO nanoparticles against carbon deposition and sintering. Owing to the reversible reconstruction of MgxNi1‐xO, this superior structure is self‐regenerative in the calcium looping dry reforming of methane process, thereby ...
Hao Xu, Chen Hou, Jiawei Zhong, Chuande Huang, Wei Wei, Jiawei Hu   +5 more
wiley   +1 more source