Results 91 to 100 of about 627,737 (260)

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

University surroundings andinfrastructures that are accessible and inclusive for all: listening to students with disabilities [PDF]

, 2018
The main topic of this article is architectural barriers and infrastructures as identified by university students with disabilities.
Morgado Camacho, Beatriz María, Moriña Díez, Anabel   +1 more
core   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

COLEGIO ALIANZA FRANCESA JEAN MERMOZ, CURICÓ, CHILE

ARQ, 2012
El replanteo de la condición constructiva y espacial de estas aulas propone fundamentalmente dos niveles de intervención a escala edilicia: una nueva envolvente traslúcida, perforada de acuerdo a diseño, y la construcción de lucernarios que proveen al ...
Guillermo Hevia, Nicolás Urzúa
doaj  

Exploring the use of new school buildings through post-occupancy evaluation and participatory action research [PDF]

, 2015
This paper presents the results of the development and testing of an integrated post-occupancy evaluation (POE) approach for teachers, staff, pupils and community members using newly constructed school buildings.
Andrea Wheeler, Blewitt J., Commission for Architecture and the Built Environment., Cox A. M., Davis J., Gaia Research., Garbarino J., Hall C., Holloway S. L., Kindon S., Krippendorff K., Mallory-Hill S., Masoud Malekzadeh, Pahl K., Pink S., Sanoff H., Upitis R., Vogel S.   +17 more
core   +3 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Design and actual energy consumption of heating educational buildings, identification of differences

Budownictwo o Zoptymalizowanym Potencjale Energetycznym, 2019
This work presents the selected results of examinations connected with an annual energy consumption CH and annual final energy demand Qk,H for heating and conducted on the group of educational buildings.
Anna Lis , Piotr Lis
doaj   +1 more source

Nitrogen: Multiple and Regional Impacts [PDF]

This report on the emission and deposition of nitrogen in the United States discusses both natural and man-made sources of nitrogen compounds, particularly oxides of nitrogen (NOx).

core  

Managers' Practices of Tobacco and Marijuana Smoking Policies in Hispanic-Occupied Multiunit Housing. [PDF]

, 2019
Purpose: This study assessed the knowledge, attitudes, and practices of managers of Hispanic-occupied multiunit housing (MUH) related to the prevalence and prevention of secondhand smoke (SHS), thirdhand tobacco smoke, and secondhand marijuana smoke ...
Baezconde-Garbanati, Lourdes, Cruz, Tess Boley, Delgado Rendon, Angelica, Soto, Claradina, Unger, Jennifer B   +4 more
core