Results 61 to 70 of about 3,952,741 (200)

A Study on Energy-Saving Technologies Optimization towards Nearly Zero Energy Educational Buildings in Four Major Climatic Regions of China

, 2019
An educational building is a kind of public building with a high density of occupants and high energy consumption. Energy-saving technology utilization is an effective measure to achieve high-performance buildings.
Yahui Du, Jing Zhao
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Impact of Green Wall and Roof Applications on Energy Consumption and Thermal Comfort for Climate Resilient Buildings

Urban Science
Nowadays, reducing energy consumption and obtaining thermal comfort are significant for making educational buildings more climate resilient, more sustainable, and more comfortable.
Cihan Turhan, Cristina Carpino, Miguel Chen Austin, Mehmet Furkan Özbey, Gulden Gokcen Akkurt   +4 more
doaj   +1 more source

Investigation into Common Decay of Educational Buildings in Malaysia

, 2014
All types of buildings will undergo decay and deterioration over a period of time. In the past few years, there have been numerous official reports in the mass media relating to building decay and failures throughout the country.
M.A. Othuman Mydin, N. Md Sani, M.Z. Sulieman, Sani N. Md, Tan S.W., Othuman Mydin M.A., S.W. Tan, Sulieman M.Z.   +7 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Indoor Environment in Educational Buildings: Assessing Natural Ventilation

, 2023
The built indoor environment has a high impact on people’s health and performance. The recent events arising from the COVID-19 global pandemic have stressed that good indoor air quality is crucial, especially in public buildings (for instance, school and
Aguilar Aguilera, Antonio Jesús, Martínez Aires, María Dolores, Hoz Torres, María Luisa de la, Ruiz Padillo, Diego Pablo   +3 more
core   +1 more source

USP7 inhibits FOXO1 activity in chronic lymphocytic leukaemia cells enhancing cell survival

Molecular Oncology, EarlyView.
CLL cells rely on BCR‐mediated signalling for survival and proliferation in part through suppression of FOXO1. FOXO1 activity is regulated by a plethora of post‐translational modifications including phosphorylation and ubiquitination. We demonstrated that dual inhibition of BCR signalling and the deubiquitinase USP7 activates FOXO1, modulating its ...
Hassan N.B. Almuhanna, Jodie Hay, Michael W. Moles, Lucy Clarke, Jennifer Cassels, Alison Sefcick, Alison M. McCaig, Heather G. Jørgensen, Alison M. Michie   +8 more
wiley   +1 more source

Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up

Molecular Oncology, EarlyView.
This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani, Laura Mariën, Caro De Weerdt, Sanne Wouters, Laure‐Anne Teuwen, Hans Prenen, Katleen Janssens, Timon Vandamme   +7 more
wiley   +1 more source

Escuelas: espacios equivocados frente a los deseados por escolares

Actualidades Investigativas en Educación, 2017
Este trabajo estudia las ideas que algunos estudiantes tienen sobre la mejora de su espacio, es decir, las proyecciones de los deseos de escolares hacia su propio centro educativo.
Amparo Alonso Sanz
doaj   +1 more source

The impact of leukocyte‐associated RNA retention on platelet RNA‐based cancer detection

Molecular Oncology, EarlyView.
Platelets carry RNA signals that may help detect cancer, but platelet samples can also retain RNA from white blood cells. We found that this retained white blood cell signal did not significantly affect machine learning cancer classification, suggesting that the cancer‐related RNA signal in platelets is largely independent of leukocyte‐associated RNA ...
Michał Sieczczyński, Krzysztof Pastuszak, Anna Samelak‐Czajka, Zuzanna Cemka, Paulina Jackowiak, Tomasz Stefaniak, Sylwia Łapińska‐Szumczyk, Jacek Jassem, Anna J. Żaczek, Matthew T. Rondina, Myron G. Best, Sjors G. J. G. In 't Veld, Anna Supernat   +12 more
wiley   +1 more source