Results 41 to 50 of about 91,215 (265)
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
Educational Expansion as a Driver of Longer Working Lives?
Comparative Population StudiesThis study investigates the contribution of educational expansion to changes in labour force participation among Europeans aged 55-74 between 2000 and 2019, while accounting for changes in educational inequalities in labour market activity.
Aart-Jan Riekhoff, Kati Kuitto
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Correlation between cognitive ability and educational attainment weakens over birth cohorts
Scientific Reports, 2023 Educational attainment is a key indicator of status and opportunity in meritocratic societies. However, it is unclear how educational expansion has affected the link between cognitive abilities and educational attainment. As a result, this study examines
Arno Van Hootegem +3 more
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Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
臺灣教育社會學研究, 2005 在臺灣的教育問題中，升學問題可說是最核心的問題，本文對於過去有關升學問題的教育社會學理論與研究做文獻檢討，試圖釐清升學與相關的教育問題之癥結所在。所得到的結論是：在臺灣社會裡，教育除了可作為提高職業、收入的工具之外，其本身也代表著很重要的社會地位，甚至於比職業、收入還要重要，這也就引發嚴重的升學競爭與壓力，給學生的學業、人格與身心發展帶來許多問題，並給教師與家長增添沉重的負擔。而臺灣許多的教育改革，如廣設高中大學的教育擴充，以及多元入學，除了要滿足強烈的升學需求、降低升學壓力之外，提升 ...
黃毅志 Yih-Jyh Hwang +1 more
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Frontiers in Public HealthBackgroundThe relationship between higher education and individual health is important for improving regional human capital for health. Considering the differences in education system development and health infrastructure between China and developed ...
Yifei Chu, Sirui Chen, Lixia Zhang
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La performance del sistema educativo argentino en las últimas décadas
Análisis, 2017 In the context of expansion and multiple transformations of the Argentine educational system, overfly discussions on institutional expansion, the evolution of the school population and samples of a system designed to generate greater inclusion. The aim of
Analía Otero, Agustina Córica
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