Results 41 to 50 of about 4,788,985 (249)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Proceedings of the Graduate Research in Education Seminar (GREduc) 2021 [PDF]

, 2021
The Graduate Research in Education Seminar (GREduc) 2021, held on 18 December 2021 and organized by the Faculty of Educational Studies, focused on the theme Envisioning Education and Human Resource Development in the 21st Century through Research and ...
Faculty of Educational Studies
core   +2 more sources

TEEM17. Track: Educational innovation [PDF]

, 2017
The track Educational Innovation1 of the International Conference Technological Ecosystems for Enhancing Multiculturality (TEEM), brings together, under the covering of the innovation, a diversity of themes from the tracks of the conference. The analysis
Fidalgo-Blanco, A., Sein-Echaluce, M.L.
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

INNOVATION IN EDUCATION

, 2022
President Shavkat Mirziyoyev: As they say, the most important task in the worldview of our people is to create an environment of innovation. Today, information technology and innovation are widespread. Not only in our country, but all over the world. Now we can see news in education and business almost everywhere.
Ramazonova Sayyora Izzat qizi, Zayniddinova Shamsiya Zayniddin qizi, Burkhanova Mamura Gulyamovna   +2 more
openaire   +2 more sources

Fostering Improvement: a reflection on equity-centered improvement across three initiatives

Frontiers in Education
In this conceptual piece, we explore the emerging definition of equity-centered improvement in education. We describe how the Center for Educational Improvement and Innovation, a partnership center at the University of Maryland College Park, both ...
Segun Eubanks, Christine M. Neumerski, Pamela Catherine Callahan, Douglas Anthony, Jean Snell, Damaries Blondonville, William Viviani, Laura Liccione, Laura Liccione   +8 more
doaj   +1 more source

EFFICIENCY OF EDUCATIONAL INNOVATIVE TECHNIQUES IN TEACHING FINANCIAL AND ECONOMIC DISCIPLINES (BASED ON SOCIAL RESEARCH)

Sovremennye Issledovaniâ Socialʹnyh Problem, 2013
Importance of the presented study consists in need of the introduction innovation educational technology when teaching in high educational institutions.
Irina Konstantinovna Bitkina
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Innovative Strategies in the Educational Field: Analysis of the Systematic Mapping of Literature

Proceedings, 2018
Educational innovation appears as a pending issue in the agendas of educational institutions at the international level. Current educational policies highlight the importance of educational innovation as a key element for improving educational quality ...
Leticia Nayeli Ramírez-Ramírez, María Soledad Ramírez-Montoya   +1 more
doaj   +1 more source

Data-driven iterative refinements to educational development services: directly measuring the impacts of consultations on course and syllabus design

To Improve the Academy, 2022
Evidence-based practice in educational development includes leveraging data to iteratively refine center for teaching and learning (CTL) services.
Chad Hershock, Emily Daniels Weiss, Jacqueline Stimson, Jessica Harrell, Katie Walsh, Laura Ochs Pottmeyer, Marisella Rodriguez, Sophie le Blanc   +7 more
doaj   +2 more sources