Results 31 to 40 of about 147,344 (265)

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

EFFICIENCY OF EDUCATIONAL INNOVATIVE TECHNIQUES IN TEACHING FINANCIAL AND ECONOMIC DISCIPLINES (BASED ON SOCIAL RESEARCH)

Sovremennye Issledovaniâ Socialʹnyh Problem, 2013
Importance of the presented study consists in need of the introduction innovation educational technology when teaching in high educational institutions.
Irina Konstantinovna Bitkina
doaj   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

INNOVATIVE DEVELOPMENT OF EDUCATIONAL SYSTEMS: CATEGORICAL MEANING [PDF]

Krymskij Naučnyj Vestnik, 2017
This article discusses the concept of «development», «innovation» and «innovation development» in relation to the educational systems, as to create a new conceptual framework for quality education.
Natalia Tretyak
doaj  

Innovative Strategies in the Educational Field: Analysis of the Systematic Mapping of Literature

Proceedings, 2018
Educational innovation appears as a pending issue in the agendas of educational institutions at the international level. Current educational policies highlight the importance of educational innovation as a key element for improving educational quality ...
Leticia Nayeli Ramírez-Ramírez, María Soledad Ramírez-Montoya   +1 more
doaj   +1 more source

Innovative kinesiology education as a criterion and predictor of innovative education

Inovacije u nastavi
Agreement with living conditions also implies compliance with the increasingly dramatic changes to which the civilization, society, and the people are exposed. The imperative response of society and civilization to changes that are inevitable but evident, with even clearer and more predictable consequences, must be the best in order to be good enough ...
Ivan Prskalo, Danimir Mandić, Vladan Pelemiš   +2 more
openaire   +2 more sources

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Data-driven iterative refinements to educational development services: directly measuring the impacts of consultations on course and syllabus design

To Improve the Academy, 2022
Evidence-based practice in educational development includes leveraging data to iteratively refine center for teaching and learning (CTL) services.
Chad Hershock, Emily Daniels Weiss, Jacqueline Stimson, Jessica Harrell, Katie Walsh, Laura Ochs Pottmeyer, Marisella Rodriguez, Sophie le Blanc   +7 more
doaj   +2 more sources

Formal, non-formal and informal education and innovation: Innovating to educate and educating to innovate

, 2023
Este documento analisa a relação entre a experiência educacional e a pessoa inovadora, e estuda a influência desta experiência no desenvolvimento de competências e capacidades de inovação nas pessoas entrevistadas. A discussão é baseada numa abordagem qualitativa, através de dez entrevistas com pessoas definidas como inovadoras, localizadas em empresas
Soto Kiewit, Luis Diego, Segura Jiménez, Alexis, Navarro Rojas, Óscar, Cedeño Rojas, Sara, Medina Díaz, Rebeca   +4 more
openaire   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source