TP53 Loss Elevates NF‐κB‐IFN‐β‐MHC‐Ia Signaling to Promote NK Cell Resistance in Osteosarcoma
Advanced Science, EarlyView.TP53 loss in a transforming or osteosarcoma cell promotes cytosolic DNA accumulation, activating NF‐κB‐dependent IFN‐β production. Autocrine IFN‐β signaling increases cell‐surface HLA‐Ia expression, strengthens inhibitory KIR signaling in natural killer cells, and thereby enables the affected cell to evade NK cell‐mediated cytotoxicity.
Guihui Qin +9 more
wiley +1 more source
Extending the age limit of paediatric care for young people from refugee backgrounds. [PDF]
BMJ Paediatr OpenCherian S +3 more
europepmc +1 more source
Towards a Compositional Framework for Describing Human Phenotypes
Advanced Science, EarlyView.The Phenotype Assembly Method (PhenoAM) decomposes phenotype variables into measurable Features and typed Qualifiers, enabling standardized, machine‐readable Phenome Data Elements (PhenoDEs) that preserve measurement context. Applied in the International Human Phenome Project (IHPP), the framework yields 58 371 PhenoDEs and supports component‐level ...
Wanting Hu +11 more
wiley +1 more source
Geographic variation and factors associated with home-based long-term care utilization across municipalities in Japan. [PDF]
BMC Glob Public HealthSakamoto JL.
europepmc +1 more source
Advanced Science, EarlyView.Tau populations with different aggregation states associate with distinct sets of proteins in the Alzheimer's disease brain. Proteomic discovery combined with single‐molecule analysis in neurons reveals dynamic associations involving proteostasis, metabolism and RNA biology.
Dorothea Böken +8 more
wiley +1 more source
Navigating Barriers and Challenges: A Narrative Review of the Experiences of Autistic People and Their Families in Latin America. [PDF]
CureusGarza Guerra AJ +3 more
europepmc +1 more source
Advanced Energy Materials, EarlyView.P2‐type sodium layered oxides have potential for high‐voltage operation but suffer from structural instability and capacity fading. This work demonstrates that synergistic Li and Ti co‐doping enhances sodium inventory, suppresses detrimental phase transitions, and activates reversible lattice oxygen redox.
Rishika Jakhar +16 more
wiley +1 more source
A Large Scale Multi‐Modal Workflow for Battery Characterization: From Concept to Implementation
Advanced Energy Materials, EarlyView.Isolated characterization techniques produce independent datasets and single‐property insights. However, progressively more holistic interpretations of battery‐material behavior is needed in the future. Here we demonstrate a coordinated multimodal workflow enabling the correlation of heterogeneous datasets and the construction of multidimensional ...
François Cadiou +34 more
wiley +1 more source
How Video‐Based Information Affects Farmers' Willingness to Pay for Drone Services
Applied Economic Perspectives and Policy, EarlyView.ABSTRACT Professional service for digital technology like agricultural drones lowers transaction costs and scope thresholds for smallholders. Meanwhile, perceptual adoption barriers remain underexplored. We conduct a two‐stage choice experiment with a randomized video‐based information treatment among 384 Chinese crop farmers to measure its effect on ...
Hua Zhang +4 more
wiley +1 more source
AI Health Services and Health Satisfaction Across Socioeconomic Groups in South Korea: National Cross-Sectional Study Using an Instrumental Variable Approach. [PDF]
J Med Internet ResZeng H, Yu C, Ouyang Y, Hu M.
europepmc +1 more source