Results 51 to 60 of about 8,423,098 (307)
Degradation mechanism of the von Willebrand factor A2 domain by nattokinase
FEBS Letters, EarlyView.Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto +3 more
wiley +1 more source
The Technology Imperative in Education [PDF]
, 2001 The technological imperative can be an insidious master. It can become the central goal of our endeavors rather than just one way through which goals can be reached. This misdirection can have very real and lasting consequences. For this reason, the basis for action in terms of information systems development and implementation must be kept visible to ...
William T. Bonner, Abhijit Gopal
openaire +2 more sources
An Agent Based approach to design Serious Game
International Journal of Serious Games, 2014 Serious games are designed to train and educate learners, opening up new learning approaches like exploratory learning and situated cognition. Despite growing interest in these games, their design is still an artisan process.
Manuel Gentile +4 more
doaj +1 more source
Positive Management Tools in Education Management [PDF]
SHS Web of Conferences, 2020 The purpose of the study is to identify the problem areas in education management and the opportunities to apply positive management tools. The authors believe that it is possible to diminish the issues related to authoritarian education management by ...
Efremkina Irina Nikolaevna +3 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Students' experiences and expectations of technologies: an Australian study designed to inform planning and development decisions [PDF]
, 2013 The pace of technological change accompanied by an evolution in social, work-based and study behaviours and norms poses particular challenges for universities as they strive to develop high quality and sustainable technology-rich learning environments ...
Jo McKenzie +5 more
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
MODERN EDUCATIONAL TECHNOLOGIES AS A CONDITION FOR THE SUCCESSFUL IMPLEMENTATION OF THE INDIVIDUAL EDUCATIONAL PROGRAM OF STUDENTS [PDF]
, 2018 In the modern model of education the attention of teachers is paid to the implementation of the individual educational route of the student. The article discusses the possibilities of modern educational technologies.
Svetlana Kalinina +5 more
core +1 more source
SCIENTIFIC EXPLANATION OF COMPOSITION OF ACIDOPHILIC-WHEY ICE CREAM, ENRICHED WITH PROTEIN
Food and Environment Safety, 2021 The work is devoted to solving the actual problem of the dairy industry - complex processing of food raw materials, expanding the range of dairy and milk-containing products of high nutritional value due to enrichment of protein, pro- and prebiotics ...
Galina POLISCHUK +6 more
doaj
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source