Results 51 to 60 of about 9,009,984 (307)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Effectiveness of Advanced Educational Technologies in the Context of Innovative Development [PDF]

, 2019
This article analyzes modern educational technologies that provide quality learning.
Inoyatova, Zulfiya, Ergasheva, Guzal
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Australian Education Technologies Trends 2018 [PDF]

, 2018
The Australian Educational Technologies Trends (AETT) report provides an overview to assist teachers, school leaders, academics and industry, in understanding and planning for the use of digital technologies in Australian schools over the next five years
Jones, M, Madsen, S, Harris, N, Sercombe, P, Speranza, A, Zagami, Jason, Flintoff, K, Vernon, K, Canning, C, Hogan, A, Joy, T, Finch, R, Shires, R, Redmond, P, Sleeman, T, et al.   +15 more
core  

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Modeling of sugar beet losses during storage in heaps [PDF]

BIO Web of Conferences
After harvesting root crops (beets, carrots, turnips) are stored in the fields or in the processing enterprises warehouse areas. Storage takes place in open space, and not always under shelters.
Korobova Lyudmila, Ivliev Maxim, Chikunov Sergey, Tolstova Irina, Arapov Denis   +4 more
doaj   +1 more source

The Educational Technology is Technology Education Manifesto

Journal of Technology Education, 2003
Published ...
openaire   +2 more sources

Students' experiences and expectations of technologies: an Australian study designed to inform planning and development decisions [PDF]

, 2013
The pace of technological change accompanied by an evolution in social, work-based and study behaviours and norms poses particular challenges for universities as they strive to develop high quality and sustainable technology-rich learning environments ...
Jo McKenzie, Malfroy, J, Maree Gosper, McKenzie, J, Gosper, M, Janne Malfroy   +5 more
core  

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source