Results 71 to 80 of about 8,705,370 (258)
Molecular Oncology, EarlyView.High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira +7 more
wiley +1 more source
Technology, Socioeconomics and Education
International Journal of Advanced Corporate Learning (iJAC), 2019 <p>One of the characteristics of the late XX century and early XXI century is the constant technological, economic, and social transformations that are clearly interrelated where any technological innovation directly influences the socio-labour sphere.
openaire +3 more sources
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
CYCLICAL MANNER OF VEGETABLE PRODUCTION INDUSTRY; THE EFFICIENCY OF GREENHOUSE BUSINESS
Овощи России, 2017 Economical efficiency of agricultural industry is a major characteristic of the level of development of an enterprise. A profit from product sale depends on volume and structure of product sales, self-cost as well as the level of sales price ...
O. N. Krylov, O. Y. Abisheva
doaj +1 more source
Modern educational technologies [PDF]
, 2015 The development of society, innovative technologies, new standards and changes in the educational process enabled the formulation of new priorities in training of different specialists.
Gryshchenko, O. V.
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Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Learning on-demand via technologies that facilitate mobility: The issues of relevancy and access
, 2006 This article discusses the role of technologies that facilitate mobility in demand-driven learning situations. The focus is not on the technologies such as mobile devices per se, but to bring sense to the pedagogical dimensions of learning through such ...
Tan, Seng Chee +2 more
core +1 more source
Mathematical Models for the Design of GRID Systems to Solve Resource-Intensive Problems
MathematicsArtificial neural networks are successfully used to solve a wide variety of scientific and technical problems. The purpose of the study is to increase the efficiency of distributed solutions for problems involving structural-parametric synthesis of ...
Valeriya V. Tynchenko +7 more
doaj +1 more source
Using the remote educational technologies in training students for psychology teaching [PDF]
The paper discusses the model of professional training of students for teaching psychology on the basis of remote educational technologies in pedagogical high school.
Seitbattalova, Aigerim
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