Results 61 to 70 of about 8,421,661 (307)

The Technology Imperative in Education [PDF]

open access: yes, 2001
The technological imperative can be an insidious master. It can become the central goal of our endeavors rather than just one way through which goals can be reached. This misdirection can have very real and lasting consequences. For this reason, the basis for action in terms of information systems development and implementation must be kept visible to ...
William T. Bonner, Abhijit Gopal
openaire   +2 more sources

Liver organoids: modelling complexity in homeostasis and disease

open access: yesFEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Tunable optical parametric oscillator based on ZnGeP2 crystal for greenhouse gas remote sensing systems

open access: yesFrontiers in Physics
This work is devoted to the development of a compact source of coherent radiation with frequency-energy characteristics and a spectral generation range that allows remote determination of background concentrations of greenhouse gases in the atmosphere ...
N. N. Yudin   +13 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

open access: yesFEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri   +5 more
wiley   +1 more source

Towards a university educational framework [PDF]

open access: yes, 2011
This poster exposes a draft university-wide educational and educational technology framework for discussion. Its purpose is to guide educational policy making, particularly for educational technologies.
Phillips, R.
core  

Translophagy—A potential link between autophagy impairment and translational errors

open access: yesFEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk   +11 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Actual educational technologies in a digital educational environment

open access: yesВестник Майкопского государственного технологического университета, 2023
At present the importance of digital educational resources in the context of the digital economy is great. Digital educational technologies play the role of a serious driver leading to constructive changes in the field of the institution of education in ...
I. A. Udzhukhu, F. A. Tuguz
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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