Results 81 to 90 of about 8,423,098 (307)

Mathematical Models for the Design of GRID Systems to Solve Resource-Intensive Problems

Mathematics
Artificial neural networks are successfully used to solve a wide variety of scientific and technical problems. The purpose of the study is to increase the efficiency of distributed solutions for problems involving structural-parametric synthesis of ...
Valeriya V. Tynchenko, Vadim S. Tynchenko, Vladimir A. Nelyub, Vladimir V. Bukhtoyarov, Aleksey S. Borodulin, Sergei O. Kurashkin, Andrei P. Gantimurov, Vladislav V. Kukartsev   +7 more
doaj   +1 more source

CYCLICAL MANNER OF VEGETABLE PRODUCTION INDUSTRY; THE EFFICIENCY OF GREENHOUSE BUSINESS

Овощи России, 2017
Economical  efficiency  of  agricultural  industry  is  a major characteristic of the level of development of an enterprise. A profit from product sale depends on volume and structure of product  sales, self-cost as well as the level of  sales price ...
O. N. Krylov, O. Y. Abisheva
doaj   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

The C‐terminal region of KIF26B is indispensable for nephron progenitor condensation and kidney formation in mice

FEBS Open Bio, EarlyView.
KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura, Kengo Furuichi, Hiromitsu Akamatsu, Naoki Yamamoto, Sako Keisuke, Akihiko Koshino, Taichiro Minami, Megumi Oshima, Akinori Hara, Norihiko Sakai, Miho Shimizu, Kenta Takahashi, Minako Yamamura, Shin‐ichi Horike, Takiko Daikoku, Kenichi Harada, Yohei Shinmyo, Hiroshi Kawasaki, Takashi Wada, Yasunori Iwata   +19 more
wiley   +1 more source

Lipopolysaccharide uptake is augmented in lipopolysaccharide‐tolerant mouse macrophage‐like cells via increased CD14 expression

FEBS Open Bio, EarlyView.
In normal (nontolerant) cells, CD14 is crucial for both LPS uptake and LPS signaling. In LPS‐tolerant cells, in which LPS‐induced TNF‐α and IFN‐β production is suppressed, there is a dramatic increase in surface CD14 expression. The overexpressed CD14 in LPS‐tolerant cells is responsible for the enhanced LPS uptake without inducing pro‐inflammatory ...
Saeka Nishihara, Takayuki Manabe, Mika Jouta, Kiyoshi Kawasaki   +3 more
wiley   +1 more source

Technology in transforming education [PDF]

, 2000
This paper addresses the relationship between societal needs and ICT. In particular it identifies how society now has different goals and needs because of the new technologies. These include a recognition of the change in mathematics and the language of reason; thus discrete processes, such as approximation, will be more important than arithmetic.
openaire   +2 more sources

Learning on-demand via technologies that facilitate mobility: The issues of relevancy and access

, 2006
This article discusses the role of technologies that facilitate mobility in demand-driven learning situations. The focus is not on the technologies such as mobile devices per se, but to bring sense to the pedagogical dimensions of learning through such ...
Tan, Seng Chee, Hung, David, Chen, Der-Thanq   +2 more
core   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Reports from CITE "Educational Technologies Evaluation in India"

, 2016
Educational technologies of all types are quickly gaining popularity across the developing world. Governments, school districts, and teachers have made investments in these technologies in hopes that they will aid learning and achievement.
Shah, Prateek, Osterweil, Scot, Allen, Stacey, Schoenfeld, Ilana, Groff, Jennifer, Kodidala, Sai Priya   +5 more
core