Results 31 to 40 of about 1,198,314 (256)

Next‐generation proteomics improves lung cancer risk prediction

open access: yesMolecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj   +4 more
wiley   +1 more source

AISR Connections Fall 2012 (2012-2013 Orientation Issue) [PDF]

open access: yes, 2012
Yearly publication of AISR Connections for 2012-2013. Issue includes: Scott Library renovations New library catalog Clinical Resources Support Jefferson Digital Commons The mission of Academic & Instructional Support & Resources (AISR) is to ...
AISR,
core   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Terms of adaptive educational technologies [PDF]

open access: yes, 2016
Сформульовано умови, які забезпечують адаптивність педагогічних технологій. Показано, що вони розширюють можливості адаптивного управління освітніми процесами.
Чеботарьов, Микола Корнійович
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon   +9 more
wiley   +1 more source

Group Leadership in Online Collaborative Learning [PDF]

open access: yes, 2005
The innovations in computer and communications technologies combined with on-going needs to deliver educational programs to students regardless of their physical locations, have lead to the innovation of distance education programs and technologies.
Kukulska-Hulme, Agnes
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

Proprietary software tools as learning aids [PDF]

open access: yes, 2007
Proprietary software tools, though not designed for educational use, have considerable educational potential. This paper describes, as case studies, the use of proprietary graphics- and audio-editing tools in two distance-taught courses produced by the ...
Jones, Allan
core  

Personalised Learning: Developing a Vygotskian Framework for E-learning [PDF]

open access: yes, 2011
Personalisation has emerged as a central feature of recent educational strategies in the UK and abroad. At the heart of this is a vision to empower learners to take more ownership of their learning and develop autonomy. While the introduction of digital
Ballard, James, Butler, Philip
core   +1 more source

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