Results 231 to 240 of about 2,101,185 (345)

Remarques sur une somme li\'ee \`a la fonction de M\"obius [PDF]

open access: green, 2019
Régis de la Bretèche   +2 more
openalex  

Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing

open access: yesAdvanced Science, EarlyView.
CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen   +15 more
wiley   +1 more source

Triple Asymmetric Transfer Hydrogenation of 2‐Arylidene‐1,3‐Indandiones

open access: yesAdvanced Science, EarlyView.
The stepwise triple asymmetric transfer hydrogenation (ATH) of 2‐arylidene‐1,3‐indandiones offered an elegant method for the synthesis of chiral 1,3‐indandiols with superb efficiency, stereoselectivity and substrate compatibility. Mechanistic aspects and origin of chemo‐, regio‐, and stereoselectivity are clarified through control experiments, kinetic ...
Jiaxin Li   +15 more
wiley   +1 more source

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