Results 261 to 270 of about 1,835,889 (325)

Engineered Biocatalyst for Enantioselective Hydrazone Reduction

Angewandte Chemie, EarlyView.
Here, we report the discovery and engineering of a hydrazone reductase (HRED) biocatalyst that promotes efficient reduction of protected hydrazones with exceptional stereocontrol. These biotransformations offer a sustainable strategy for synthesizing valuable chiral N─N containing products that are commonly found in pharmaceuticals and agrochemicals ...
Amy E. Hutton, Fei Zhao, Elizabeth Ho, Jack Domenech, Vanessa Harawa, Murray J. B. Brown, Gideon Grogan, Phillip D. Clayman, Nicholas J. Turner, Anthony P. Green   +9 more
wiley   +1 more source

Burnout and associated risk factors among nurses working in COVID-19 isolation hospitals: a cross-sectional study in Egypt. [PDF]

J Egypt Public Health Assoc
Ibraheim OG, Shehata AI, Elhoseny TA.
europepmc   +1 more source

The ATM Kinase Inhibitor AZD0156 Is a Potent Inhibitor of Plasmodium Phosphatidylinositol 4‐Kinase (PI4Kβ) and Is an Attractive Candidate for Medicinal Chemistry Optimization Against Malaria

Angewandte Chemie, EarlyView.
AZD0156, an ATM kinase inhibitor in clinical development, shows promising multistage antiplasmodial activity by targeting Plasmodium falciparum phosphatidylinositol 4‐kinase (PfPI4Kβ). With an improved specificity profile relative to other PfPI4Kβ inhibitors and moderate efficacy in a P.
John G. Woodland, Dina Coertzen, Kathryn J. Wicht, Virginia Franco Hidalgo, Charisse Flerida A. Pasaje, Luiz C. Godoy, Tarrick Qahash, Mmakwena M. Mmonwa, Godwin A. Dziwornu, Lynn Wambua, Sarah Harries, Constance M. Korkor, Mathew Njoroge, Liezl Krugmann, Dale Taylor, Meta Leshabane, Henrico Langeveld, Tayla Rabie, Janette Reader, Mariëtte van der Watt, Nelius Venter, Erica Erlank, Ayesha S. Aswat, Lizette L. Koekemoer, Tomas Yeo, Jin H. Jeon, David A. Fidock, Francisco Javier Gamo, Sergio Wittlin, Jacquin C. Niles, Manuel Llinas, Lauren B. Coulson, Lyn‐Marié Birkholtz, Kelly Chibale   +33 more
wiley   +1 more source

Aspen-EE: An Agent-Based Model of Infrastructure Interdependency

, 2000
David Barton, Eric Eidson, David Schoenwald, Kevin L. Stamber, Robert Reinert   +4 more
openalex   +2 more sources

Effect of Cladribine Tablets on the Pharmacokinetics of a Combined Oral Contraceptive in Pre-Menopausal Women With Relapsing Multiple Sclerosis. [PDF]

Clin Transl Sci
Hermann R, Hellwig K, Gaikwad S, Galazka A, Bytyqi A, Jack D, Krebs-Brown A, Vetter C, Nolting A, Venkatakrishnan K, Dong JQ.   +10 more
europepmc   +1 more source

Integrative Lattice and Surface Engineering of Nanoscale Fe0 for Superior Dechlorination of Trichloroethene in Groundwater: Coordination in Reactivity, Selectivity, and Stability

Angewandte Chemie, EarlyView.
A lattice and surface engineering strategy was employed to synthesize a novel core‐shell nanomaterial for superior reductive dechlorination of trichloroethene. In this design, FeNi serves as the core and FeS as the shell. Core composition and shell properties interactively determine materials’ performance, and the optimal material exhibited 242.7‐fold ...
Feilong Gao, Guofang Xu, Mingyi Zhang, Honghong Lyu, Han Wu, Jingchun Tang, Xinhua Xu, Jianzhong He   +7 more
wiley   +1 more source

Effect of psychologically induced stress on symptom perception & autonomic nervous system response of patients (PTS.) With erosive esophagitis (EE) and non-erosive reflux disease (NERD)

, 2000
Ronnie Fass, Isaac Malagon, Bruce D. Naliboff, Gloria Pulliam, Nitzan Peleg, Emeran A. Mayer   +5 more
openalex   +1 more source

Enriched environment alleviates NLRP3 inflammasome mediated neuroinflammation in diabetes complicated with depression rats. [PDF]

Sci Rep
Wang H, Liang Q, Wen Z, Ma W, Ji S, Zhang H, Zhang X.   +6 more
europepmc   +1 more source

Bayesian Meta‐Learning for Few‐Shot Reaction Outcome Prediction of Asymmetric Hydrogenation of Olefins

Angewandte Chemie, EarlyView.
A Bayesian meta‐learning framework is proposed for reaction outcome prediction in low‐data settings. It utilizes a literature‐mined dataset on asymmetric hydrogenation of olefins to build a pre‐trained model. This meta‐model is shown to return better predictions as compared to single‐tasks methods, such as random forest and graph neural networks, given
Sukriti Singh, José Miguel Hernández‐Lobato   +1 more
wiley   +1 more source

Dynamic Kinetic Asymmetric Hydroacylation: Racemization by Soft Enolization. [PDF]

J Am Chem Soc
Xu M, Corio SA, Warnica JM, Kuker EL, Lu A, Hirschi JS, Dong VM.   +6 more
europepmc   +1 more source