Results 311 to 320 of about 2,013,374 (364)

Is a Malleable Active Site Loop the Key to High Substrate Promiscuity? Hybrid, Biocatalytic Route to Structurally Diverse Taxoid Side Chains with Remarkable Dual Stereocontrol

Angewandte Chemie, EarlyView.
A highly stereoselective, dynamic reductive kinetic resolution (DYRKR) entry into myriad Taxotere‐like side chains with Clostridium acetobutylicum alcohol dehydrogenase (CaADH) enzyme is reported. Follow‐on cross couplings expand the structural diversity of the library (36 total examples).
Gaurav P. Kudalkar, Florian Leidner, Nivesh Kumar, Jared L. Hass, Peter Madzelan, Douglas R. Powell, Victor W. Day, Pierre Le Magueres, Joseph D. Ferrara, Lee M. Daniels, Akihito Yamano, Sho Ito, Wei Niu, Helmut Grubmüller, Mark A. Wilson, David B. Berkowitz   +15 more
wiley   +1 more source

A novel data-driven model to define physical activity metrics and predict mortality in patients with chronic obstructive pulmonary disease. [PDF]

Sci Rep
Deng Q, van 't Hul A, van Hees H, Djamin R, Vaes AW, Spruit MA.   +5 more
europepmc   +1 more source

Metabolic Engineering of the 5‐Aminolevulinate Biosynthetic Pathway in E. coli Improves Efficiency of Hemoprotein‐Based Biocatalysis

Angewandte Chemie, EarlyView.
We have engineered the heme biosynthetic pathway in E. coli to develop an efficient cofactor supplementation system for hemoproteins. Through the incorporation of the heterogeneous C4 pathway, the engineered cells significantly increase the expression levels of active holohemoproteins and enhance the efficiency of whole‐cell and lysate‐based ...
Shunsuke Kato, Miteki Abe, Nobuyuki Okahashi, Shinya Ariyasu, Fumio Matsuda, Osami Shoji, Takashi Hayashi   +6 more
wiley   +1 more source

Early Onset Memory Deficit of WMI Rats Compared to Their Nearly Isogenic WLIs Is Reversed by Enriched Environment in Females. [PDF]

Genes Brain Behav
Ji MT, Przybyl KJ, Harter AM, Nemesh M, Jenz ST, Yamazaki A, Kim C, Mulligan MK, Chen H, Redei EE.   +9 more
europepmc   +1 more source

Intramolecular Lithiation‐Borylation for the Stereoselective Synthesis of Cyclopentyl and Cyclobutyl Bis‐Boronic Esters

Angewandte Chemie, EarlyView.
Cyclopentyl and cyclobutyl 1,3‐bis‐boronic esters have been prepared from benzylic carbamates with excellent regio‐, diastereo‐ and enantioselectivity. The method enables the asymmetric cycloalkanes bearing bis‐boronic esters which can be manipulated independently. Abstract Saturated carbocycles are common motifs in natural products and pharmaceuticals,
Christopher J. Cope, Margherita Zanini, Malcolm R. P. George, Daniel Otero, Jana Sendra, Adam Noble, Julien Lefranc, Raphaël Robiette, Varinder K. Aggarwal   +8 more
wiley   +1 more source

Microglia: Mediators of experience-driven corrective neuroplasticity. [PDF]

IBRO Neurosci Rep
Rogerson-Wood L, Sawatari A, Leamey CA.
europepmc   +1 more source

Food seeking suppression by environmental enrichment accompanies cell type- and circuit-specific prelimbic cortical modulation

Peters KZ, Agbude R, Steele OG, Suto N, Koya E.   +4 more
europepmc   +1 more source

Nutritional composition and prediction of energy values of poultry offal meal and meat and bone meal for broilers. [PDF]

Trop Anim Health Prod
de Oliveira CRC, Rabello CB, Rodrigues PB, da Costa Lopes C, Silva BA, Lopes EC, Ludke MDCMM, de Souza LFA, Nascimento JCDS, da Silva WA, Ribeiro AG, Carvalho LRRA, Batista Dos Santos MJ.   +12 more
europepmc   +1 more source

Organocatalytic asymmetric synthesis of Tröger's bases. [PDF]

Nat Commun
Li YW, Mo NN, Zhang H, Wu JX, Han TJ, Xiao X, Wei D, Mei GJ.   +7 more
europepmc   +1 more source

Fecal or bacterial transplantation in mice transfer environment-induced brain plasticity and associated behavioral changes. [PDF]

Front Physiol
Marrocco F, Khan R, Reccagni A, Lin X, Delli Carpini M, Iebba V, D'Alessandro G, Limatola C.   +7 more
europepmc   +1 more source