Results 101 to 110 of about 69,972 (303)
Taking Farmers off Welfare. The EEC Commission’s Memorandum “Agriculture 1980” of 1968
, 2010 The so-called Mansholt Plan of 1968 was the first of many attempts to reform the Common Agricultural Policy (CAP). It was a radical proposal to transform European agriculture and to modernise agricultural structures.
Seidel, K.
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Integrated VLC/RF With Adaptive Power Control for Reliable Cluster-Based VANET Communications
IEEE AccessIn Vehicular Ad Hoc Networks (VANETs), ensuring reliable, energy-efficient communication under varying traffic densities remains a major challenge, particularly when relying completely on conventional Radio Frequency (RF) communication.
Ahmed M. El-Eraki +4 more
doaj +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Gynecology and Obstetrics Clinical MedicineEndometrial carcinoma (EC) is one of the most common malignancies of the female reproductive system, with an increasing incidence and mortality rate. Endometrioid EC (EEC) was the most common type of EC.
Xiaobo Zhang, Yixuan Zhen
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
, 2014 Aim. Case report. EEC syndrome is a genetic developmental disorder characterized by ectrodactyly, ectodermal dysplasia, and orofacial clefts (cleft lip/palate).
LUGLIÈ, Pietrina Francesca +2 more
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Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source