Results 91 to 100 of about 616,724 (329)

Activation of Kir4.1 Channels by 2‐D08 Promotes Myelin Repair in Multiple Sclerosis

open access: yesAdvanced Science, EarlyView.
Multiple sclerosis causes myelin loss and neurological dysfunction. This study shows that 2‐D08, a small molecule targeting Kir4.1 channels, promotes OPCs differentiation via FYN tyrosine kinase phosphorylation and the FYN/MYRF pathway. It significantly improves myelin repair and motor deficits in EAE mice and marmosets, highlighting its potential as a
Mingdong Liu   +17 more
wiley   +1 more source

Autism and mild epilepsy associated with a de novo missense pathogenic variant in the GTPase effector domain of DNM1

open access: yesAmerican Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView., 2023
Abstract Dynamin 1 is a GTPase protein involved in synaptic vesicle fission, which facilitates the exocytosis of neurotransmitters necessary for normal signaling. Pathogenic variants in the DNM1 gene are associated with intractable epilepsy, often manifested as infantile spasms at onset, developmental delay, and a movement disorder, and are located in ...
Davide Mei   +4 more
wiley   +1 more source

Navigating the multifaceted landscape of culture and social work

open access: yesJournal of Comparative Social Work, 2020
Faced with increased global migration, there is a growing concern that social workers need more training in- and knowledge of culture and ethnicity.
Maria Gussgard Volckmar-Eeg   +1 more
doaj   +1 more source

Distributed Temporal Coding of Visual Memory Categories in Human Hippocampal Neurons Revealed by an Interpretable Decoding Model

open access: yesAdvanced Science, EarlyView.
This study examines how the human hippocampus encodes visual memory categories. By decoding spiking activity from CA3 and CA1 neurons using an interpretable model, it reveals that category‐specific representations emerge from distributed temporal coding.
Xiwei She   +17 more
wiley   +1 more source

Parvalbumin Interneuron‐Dependent Hippocampal Neurogenesis Evoked by Prolonged Rhythmic Light Flicker

open access: yesAdvanced Science, EarlyView.
This study demonstrates that prolonged rhythmic 40 Hz light flicker enhances spatial learning by stimulating PV interneuron‐dependent neurogenesis. The light flicker selectively activates PV interneurons, which enhances GABAergic support for the integration of immature neurons in the adult dentate gyrus.
Hai Yan   +16 more
wiley   +1 more source

Enhanced Brain‐Heart Connectivity as a Precursor of Reduced State Anxiety after Therapeutic Virtual Reality Immersion

open access: yesAdvanced Science, EarlyView.
This study shows that enhanced brain‐to‐heart coupling is a precursor of anxiety reduction following a virtual reality‐based non‐pharmacological intervention. Driven by midline beta rhythms, this effect suggests the involvement of central‐autonomic interactions.
Idil Sezer   +6 more
wiley   +1 more source

AADNet: An End-to-End Deep Learning Model for Auditory Attention Decoding

open access: yesIEEE Transactions on Neural Systems and Rehabilitation Engineering
Auditory attention decoding (AAD) is the process of identifying the attended speech in a multi-talker environment using brain signals, typically recorded through electroencephalography (EEG). Over the past decade, AAD has undergone continuous development,
Nhan Duc Thanh Nguyen   +4 more
doaj   +1 more source

Neutron Electric Dipole Moment from colored scalars⋆

open access: yesEPJ Web of Conferences, 2014
We present new contributions to the neutron electric dipole moment induced by a color octet, weak doublet scalar, accommodated within a modified Minimal Flavor Violating framework.
Fajfer Svjetlana, Eeg Jan O.
doaj   +1 more source

Wireless Soft Athlete Bioelectronics for Monitoring Carbon Dioxide Ventilation and Physiological Performance

open access: yesAdvanced Science, EarlyView.
A wireless soft athlete bioelectronic system offers a real‐time continuous monitoring of various physiological signals and metabolites during exercise. Abstract Wearable devices have become essential tools for monitoring athletes' health and performance.
Tae Woog Kang   +12 more
wiley   +1 more source

Sleep Deprivation Activates a Conserved Lactate‐H3K18la‐RORα Axis Driving Neutrophilic Inflammation Across Species

open access: yesAdvanced Science, EarlyView.
Sleep deprivation triggers systemic immune activation characterized by neutrophil accumulation and cytokine release. This study reveals a conserved metabolic‒epigenetic mechanism whereby lactate‐induced H3K18 lactylation upregulates RORα expression, promoting neutrophilic inflammation.
Ren Zhou   +15 more
wiley   +1 more source

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