Results 101 to 110 of about 33,071 (276)

Targeting Endogenous Lipophagy: A Novel Strategy to Enhance MSC Osteogenesis and Mineralization for Senile Osteoporosis Therapy

open access: yesAdvanced Science, EarlyView.
Schematic representation of the role of lipophagy in bone mesenchymal stem cells(MSCs). In healthy MSCs, functional lipophagy efficiently degrades lipid droplets to support oxidative phosphorylation and cellular energy production, thereby facilitating osteogenic differentiation and matrix mineralization.
Chaoqiang Chen   +8 more
wiley   +1 more source

Fabricación de torres para Aerogeneradores

open access: yesRevista Centro Azúcar, 2013
En Cuba con el objetivo de sustituir los combustibles fósiles, con la ventaja adicional de evitar la emisión a la atmósfera de CO2, se ha implementado un programa estratégico de desarrollo de la energía eólica a mediano plazo que contempla la instalación
Leicy Zuazo Yera
doaj  

Intestinal Source Control of Lipid Metabolism by Enzyme‐Probiotic Encapsulated, Spatiotemporal Crosslinked, and Small Intestine‐Adhesive Hydrogel Microspheres

open access: yesAdvanced Science, EarlyView.
A thiol‐modified alginate hydrogel microsphere‐encapsulated enzyme‐probiotic biohybrid (AKK‐COD) system has been developed to address the spatiotemporal delivery and colonization challenges of small intestine‐targeted probiotic for lipid metabolism regulation. The system exerts sequential functions of intragastric protection, small intestinal adhesion,
Xiaolin Wu   +10 more
wiley   +1 more source

Atroposelective Construction of Axially Chiral Tetraarylethenes Via NHC‐Catalyzed Desymmetrization

open access: yesAdvanced Science, EarlyView.
We report the first NHC‐catalyzed atroposelective synthesis of axially chiral TAEs via oxidative desymmetrization of prochiral TAE dialdehydes. This catalytic strategy operates under mild conditions and accommodates a broad range of phenolic and nitrogen nucleophiles, delivering diverse axially chiral TAEs in good yields and up to 99% ee.
Yang‐Ze Zheng   +6 more
wiley   +1 more source

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

open access: yesAdvanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang   +14 more
wiley   +1 more source

"The European Employment Strategy and Welfare State Reform: The Case of Increased Labour Market Participation of Older Workers" [PDF]

open access: yes, 2005
The European Employment Strategy (EES) aims at increasing labour market participation and employment in the member states of the European Union through common objectives, supranational guidelines and recommendations addressed to EU member states while ...
Rhein, Thomas., Eichhorst, Werner
core  

CK2α Deficiency Drives Myocardial Fibrosis via Desmin‐Induced Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
CK2α preserves mitochondrial homeostasis by phosphorylating Desmin to recruit Cryab, ensuring proper filament assembly. CK2α deficiency disrupts this interaction, causing mitochondrial dysfunction, metabolic shifts, bioenergetic failure, and oxidative stress—ultimately establishing a pro‐fibrotic environment that drives cardiac fibrosis.
Canjie Ma   +12 more
wiley   +1 more source

Descriptive statistics–EES using different width values.

open access: yes
Descriptive statistics–EES using different width values.
Robert Zůvala (12015065)   +4 more
core   +1 more source

Skuldbindingar Íslands í loftslagsmálum samkvæmt EES-samningnum

open access: yes, 2020
Á undanförnum árum hefur löggjöf ESB, á sviði loftslagsmála, tekið miklum breytingum vegna alþjóðlegra skuldbindinga sambandsins og aðildarríkja þess.
Hlín Gísladóttir 1995-
core  

Over de digitale expertise van de Nederlandse RVC [PDF]

open access: yes, 2019
Digitaliseringstrategieën kunnen worden gericht op expansie of toetreding in gerelateerde sectoren, ongerelateerde sectoren, verbetering van processen en het ontwikkelen van geheel nieuwe producten of diensten (bijvoorbeeld shared services, demand-led ...
Ees, van, Hans; id_orcid   +2 more
core  

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